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首页> 美国卫生研究院文献>BMC Gastroenterology >Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial
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Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial

机译：一项多中心随机对照试验的研究方案用于比较缺血性终末双重低温加氧机灌注与静态冷库在预防循环死亡后捐献的肝移植物移植后非解剖性胆道狭窄方面的功效：DHOPE-DCD试验

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BackgroundThe major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been proposed as an alternative strategy for organ preservation which reduces ischemia-reperfusion injury (IRI). Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is associated with less IRI, improved hepatocellular function, and better preserved mitochondrial and endothelial function compared to conventional static cold storage (SCS). Moreover, DHOPE was safely applied with promising results in a recently performed phase-1 study. The aim of the current study is to determine the efficacy of DHOPE in reducing the incidence of NAS after DCD liver transplantation.
机译：背景技术循环死亡（DCD）供体捐赠后的肝脏移植肝移植的主要问题仍然是非解剖性胆道狭窄（NAS）的高发生率。已经提出了机器灌注作为器官保存的替代策略，其减少了缺血-再灌注损伤（IRI）。实验研究表明，与传统的静态冷库（SCS）相比，双重低温加氧机灌注（DHOPE）与更少的IRI，改善的肝细胞功能以及更好地保存的线粒体和内皮功能有关。此外，在最近进行的1期研究中，DHOPE安全地应用于了有希望的结果。本研究的目的是确定DHOPE降低DCD肝移植后NAS发生率的功效。

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