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首页> 美国卫生研究院文献>Biophysical Reviews >BAR domain proteins—a linkage between cellular membranes signaling pathways and the actin cytoskeleton
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BAR domain proteins—a linkage between cellular membranes signaling pathways and the actin cytoskeleton

机译：BAR域蛋白-细胞膜信号传导途径和肌动蛋白细胞骨架之间的联系

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摘要

Actin filament assembly typically occurs in association with cellular membranes. A large number of proteins sit at the interface between actin networks and membranes, playing diverse roles such as initiation of actin polymerization, modulation of membrane curvature, and signaling. Bin/Amphiphysin/Rvs (BAR) domain proteins have been implicated in all of these functions. The BAR domain family of proteins comprises a diverse group of multi-functional effectors, characterized by their modular architecture. In addition to the membrane-curvature sensing/inducing BAR domain module, which also mediates antiparallel dimerization, most contain auxiliary domains implicated in protein-protein and/or protein-membrane interactions, including SH3, PX, PH, RhoGEF, and RhoGAP domains. The shape of the BAR domain itself varies, resulting in three major subfamilies: the classical crescent-shaped BAR, the more extended and less curved F-BAR, and the inverse curvature I-BAR subfamilies. Most members of this family have been implicated in cellular functions that require dynamic remodeling of the actin cytoskeleton, such as endocytosis, organelle trafficking, cell motility, and T-tubule biogenesis in muscle cells. Here, we review the structure and function of mammalian BAR domain proteins and the many ways in which they are interconnected with the actin cytoskeleton.Electronic supplementary materialThe online version of this article (10.1007/s12551-018-0467-7) contains supplementary material, which is available to authorized users.
机译：肌动蛋白丝组装通常与细胞膜结合发生。大量蛋白质位于肌动蛋白网络与膜之间的界面，扮演着多种角色，例如引发肌动蛋白聚合，调节膜曲率和信号传导。 Bin /两亲性/ Rvs（BAR）域蛋白已牵涉到所有这些功能。 BAR结构域蛋白家族包含多种多样的多功能效应子，其特征在于其模块化结构。除了膜曲率传感/诱导BAR结构域模块还介导反平行二聚化，大多数还包含与蛋白质-蛋白质和/或蛋白质-膜相互作用有关的辅助域，包括SH3，PX，PH，RhoGEF和RhoGAP域。 BAR域本身的形状各不相同，从而产生了三个主要的子族：经典的月牙形BAR，扩展性更高且弯曲程度较小的F-BAR和反曲率I-BAR子族。该家族的大多数成员都牵涉需要肌动蛋白细胞骨架动态重塑的细胞功能，例如内吞，细胞器运输，细胞运动和肌肉细胞中的T管生物发生。在这里，我们回顾了哺乳动物BAR结构域蛋白的结构和功能以及它们与肌动蛋白细胞骨架相互连接的多种方式。电子补充材料本文的在线版本（10.1007 / s12551-018-0467-7）包含补充材料，可供授权用户使用。

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