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首页> 美国卫生研究院文献>The Journal of Neuroscience >Evidence for collateral projections by neurons in Ammons horn the dentate gyrus and the subiculum: a multiple retrograde labeling study in the rat
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Evidence for collateral projections by neurons in Ammons horn the dentate gyrus and the subiculum: a multiple retrograde labeling study in the rat

机译：阿蒙角齿状回和下丘脑神经元侧支投射的证据：在大鼠中进行的多个逆行标记研究

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Although it has been recognized for some years that each cytoarchitectonic field of Ammon's horn and the subiculum gives rise to a specific pattern of cortical and subcortical projections, it has not been clear whether these various projections arise from different populations of neurons within each field or whether they arise as collaterals from an essentially homogeneous population of cells. We have examined this problem, and the related issue of the origin of the commissural and ipsilateral associational projections of the dentate gyrus, by injecting retrogradely transported fluorescent dyes into two or more of the relevant projection fields in adult rats and subsequently examining the brains for doubly or triply labeled neurons. It is clear from these experiments that at least two of the known efferent projections of field CA1 (to the septum and to the entorhinal cortex) arise from the same pyramidal neurons and also that the commissural, ipsilateral associational, septal, and subicular projections of the other major field of Ammon's horn--field CA3-- similarly are due to collaterals. Double-labeling experiments also indicate that at least 80% of the cells in the deep hilar region of the dentate gyrus give rise to both an ipsilateral (associational) and a crossed (or commissural) projection to the dentate granule cells. In contrast, the projection neurons in the dorsal part of the subiculum form a quite heterogeneous population; cells that project to both the septum and the entorhinal area are intermingled with others that project to one or the other area but not to both. The cortical and cortico-subcortical connections of the hippocampal formation thus appear to be quite different from those of the neo-cortex, and the existence of such an extensive system of collateral projections clearly has important consequences for studies of the development of the hippocampus and of its response to selective deafferentation.
机译：尽管多年来已经认识到Ammon的角和下丘脑的每个细胞结构场都会产生特定的皮层和皮层下投射模式，但尚不清楚这些不同的投射是否来自每个视野内不同的神经元种群，还是是否它们是从本质上同质的细胞群体中产生的抵押品。我们已经通过向成年大鼠的两个或多个相关投影场中注射逆行转运的荧光染料并随后对大脑进行双倍检查，研究了这个问题以及齿状回的连合和同侧联合投影的起源的相关问题。或三重标记的神经元。从这些实验中可以清楚地看到，至少已知的两个场CA1传出投影（到中隔和内嗅皮层）来自相同的锥体神经元，并且它们的连合，同侧缔合，间隔和亚瓣膜投影Ammon的号角的其他主要领域-CA3--同样是由于抵押品。双重标记实验还表明，在齿状回的深部肺门区域中至少有80％的细胞会向齿状颗粒细胞产生同侧（结合）和交叉（或合子）投影。相比之下，亚下丘背侧的投射神经元形成了一个非常异质的种群。既向隔膜又向内膜区域投射的细胞与向一个或另一个区域但向两者都不投射的细胞混合在一起。因此，海马结构的皮层和皮层下皮质连接似乎与新皮层的连接完全不同，如此广泛的侧支投影系统的存在显然对研究海马和海马的发育具有重要的意义。它对选择性脱除咖啡因的反应。

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