首页> 美国卫生研究院文献>BMC Cancer >Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy and total mesorectal excision or nonoperative management

【2h】

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy and total mesorectal excision or nonoperative management

机译：直肠腺癌的器官保存：一项II期随机对照试验评估在局部晚期直肠癌患者中进行化学放疗诱导或巩固化疗以及全直肠系膜切除或非手术治疗的3年无病生存率

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundTreatment of patients with non-metastatic, locally advanced rectal cancer (LARC) includes pre-operative chemoradiation, total mesorectal excision (TME) and post-operative adjuvant chemotherapy. This trimodality treatment provides local tumor control in most patients; but almost one-third ultimately die from distant metastasis. Most survivors experience significant impairment in quality of life (QoL), due primarily to removal of the rectum. A current challenge lies in identifying patients who could safely undergo rectal preservation without sacrificing survival benefit and QoL.

机译：背景技术非转移性局部晚期直肠癌（LARC）患者的治疗包括术前放化疗，全直肠系膜切除术（TME）和术后辅助化疗。这种三联疗法可为大多数患者提供局部肿瘤控制。但几乎有三分之一最终死于远处转移。大多数幸存者的生活质量（QoL）受到严重损害，这主要是由于直肠切除所致。当前的挑战在于确定可以安全地进行直肠保存而不牺牲生存获益和生活质量的患者。

著录项

期刊名称 BMC Cancer
作者
J. Joshua Smith; Oliver S. Chow; Marc J. Gollub; Garrett M. Nash; Larissa K. Temple; Martin R. Weiser; José G. Guillem; Philip B. Paty; Karin Avila; Julio Garcia-Aguilar;
展开▼
作者单位

展开▼
年(卷),期 2015(15),-1
年度 2015
页码 767
总页数 13
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Rectal cancer Non-operative management Chemoradiation therapy Total mesorectal excision. Total neoadjuvant therapy Clinical complete response Pathologic complete response;

机译：直肠癌;非手术治疗;化学放疗;直肠系膜全切。完全新辅助治疗;临床完全缓解;病理完全缓解;

相似文献

外文文献
中文文献

1. 对可切除的中/低位直肠癌是/否进行术前放化疗的全直肠系膜切除术研究:一项前瞻性、单中心、随机试验的长期分析 [J] . Fulong Wang, Xiaojun Wu, Peirong Ding, 癌症（英文版） . 2019,第005期
2. Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management [J] . J. Joshua Smith, Oliver S. Chow, Marc J. Gollub, BMC Cancer . 2015,第1期

机译：直肠腺癌的器官保存：一项II期随机对照试验，评估了局部晚期直肠癌患者的3年无病生存率，这些患者接受化学放疗，诱导或巩固化疗以及全直肠系膜切除或非手术治疗
3. Upfront radical surgery with total mesorectal excision followed by adjuvant FOLFOX chemotherapy for locally advanced rectal cancer (TME-FOLFOX): an open-label, multicenter, phase II randomized controlled trial [J] . Jii Bum Lee, Han Sang Kim, Inkyung Jung, Trials . 2020,第1期

机译：全部介性切除的前期自由基手术，然后进行佐剂Folfox化疗，用于局部晚期直肠癌（TME-FOLFOX）：开放标签，多中心，第二期随机对照试验
4. Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial [J] . Breugom A. J., van Gijn W., Muller E. W., Annals of oncology: official journal of the European Society for Medical Oncology . 2015,第4期

机译：术前放化疗联合全直肠系膜切除术治疗直肠癌患者的辅助化疗：荷兰结肠直肠癌组（DCCG）随机III期试验
5. Upfront radical surgery with total mesorectal excision followed by adjuvant FOLFOX chemotherapy for locally advanced rectal cancer (TME-FOLFOX): an open-label multicenter phase II randomized controlled trial [O] . Jii Bum Lee, Han Sang Kim, Inkyung Jung, 2020

机译：全直肠系膜全切除的前期根治性手术然后辅以FOLFOX化疗治疗局部晚期直肠癌（TME-FOLFOX）：一项开放性多中心II期随机对照试验
6. Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management [O] . 2015

机译：直肠腺癌的器官保存：一项II期随机对照试验，评估在局部晚期直肠癌患者中进行化学放疗，诱导或巩固化疗以及全直肠系膜切除或非手术治疗的3年无病生存率

摘要

著录项

相似文献

相关主题

期刊订阅