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A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

机译：脆弱位点基因FATS中的功能性遗传变异调节三位女性的乳腺癌风险

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BackgroundThe fragile-site associated tumor suppressor (FATS, formerly known as C10orf90), a regulator of p53-p21 pathway has been involved in the onset of breast cancer. Recent data support the idea that the crosstalk between FATS and p53 may be of physiological importance for reproduction during evolution. The aim of the current study was to test the hypothesis that FATS genetic polymorphism can influence the risk of breast cancer.

机译：背景脆弱部位相关的肿瘤抑制因子（FATS，前身为C10orf90），是p53-p21途径的调节剂，已经参与了乳腺癌的发作。最近的数据支持了这样一个想法，即FATS和p53之间的串扰对于进化过程中的繁殖可能具有生理重要性。本研究的目的是检验FATS基因多态性可能影响乳腺癌风险的假设。

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期刊名称 BMC Cancer
作者
Fangfang Song; Jun Zhang; Li Qiu; Yawen Zhao; Pan Xing; Jiachun Lu; Kexin Chen; Zheng Li;
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作者单位

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年(卷),期 2015(15),-1
年度 2015
页码 559
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Breast cancer FATS Single-nucleotide polymorphism p53 Parity;

机译：乳腺癌;FATS;单核苷酸多态性;p53;奇偶性;

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专利

1. A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women [J] . Fangfang Song, Jun Zhang, Li Qiu, BMC Cancer . 2015,第1期

机译：脆弱位点基因FATS中的功能性遗传变异调节三位女性的乳腺癌风险
2. Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women [J] . FejermanL., SternM.C., ZivE., Carcinogenesis . 2013,第8期

机译：遗传血统改变了西班牙裔和非西班牙裔白人女性的遗传风险变异与乳腺癌风险之间的关联
3. Genetic variants In interleukin genes are associated with breast cancer risk and survival in a genetically admixed population; the Breast Cancer Health Disparities Study [J] . Martha L.SIattery, Jennifer S.Herrick, Gabriella Torres-Meila, Carcinogenesis . 2014,第8期

机译：白细胞介素基因的遗传变异与基因混合人群中的乳腺癌风险和生存有关。乳腺癌健康差异研究
4. Dietary Omega-3 Fatty Acids, Genetic Variation and Risk of Breast and Prostate Cancers [C] . Julian Mauermann, Frederic Pouliot, Vincent Fradet Inaugural Conference of the World Council on Genetics, Nutrition and Fitness for Health on the theme "Health Agriculture, Healthy Nutrition, Healthy People . 2011

机译：膳食ω-3脂肪酸，遗传变异和乳腺癌和前列腺癌的风险
5. Molecular stress signaling in breast epithelial cells: Characterization of the regulation of the breast cancer susceptibility gene 1 (BCRA1) by stress signaling, and, Design of an epidemiological study examining the effect of glucocorticoid receptor genetic variants on breast cancer risk [D] . Antonova, Lilia 2008

机译：乳腺上皮细胞中的分子应激信号传递：通过应激信号传递来表征乳腺癌易感基因1（BCRA1）的调节，以及一项流行病学研究的设计，旨在研究糖皮质激素受体基因变异对乳腺癌风险的影响
6. Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women [O] . Laura Fejerman, Mariana C. Stern, Elad Ziv, -1

机译：遗传血统改变了西班牙裔和非西班牙裔白人女性的遗传风险变异与乳腺癌风险之间的关联
7. A functional genetic variant in fragile-site gene modulates the risk of breast cancer in triparous women [O] . 2015

机译：脆弱位点基因的功能性遗传变异调节三位女性的乳腺癌风险

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

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