Automatic detection of exonic splicing enhancers (ESEs) using SVMs

机译：使用SVM自动检测外显子剪接增强剂（ESE）

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BackgroundExonic splicing enhancers (ESEs) activate nearby splice sites and promote the inclusion (vs. exclusion) of exons in which they reside, while being a binding site for SR proteins. To study the impact of ESEs on alternative splicing it would be useful to have a possibility to detect them in exons. Identifying SR protein-binding sites in human DNA sequences by machine learning techniques is a formidable task, since the exon sequences are also constrained by their functional role in coding for proteins.

机译：背景外显子剪接增强子（ESE）激活附近的剪接位点并促进它们所驻留的外显子的包涵（相对于排斥），同时是SR蛋白的结合位点。为了研究ESE对替代剪接的影响，可能有可能在外显子中检测到它们。通过机器学习技术鉴定人DNA序列中SR蛋白的结合位点是一项艰巨的任务，因为外显子序列也受其在编码蛋白质中的功能作用的约束。

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期刊名称 BMC Bioinformatics
作者
Britta Mersch; Alexander Gepperth; Sándor Suhai; Agnes Hotz-Wagenblatt;
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年(卷),期 2008(9),-1
年度 2008
页码 369
总页数 15
原文格式 PDF
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中图分类应用微生物学;生化遗传学;生化药理学;
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专利

1. Automatic detection of exonic splicing enhancers (ESEs) using SVMs [J] . Britta Mersch, Alexander Gepperth, Sándor Suhai, BMC Bioinformatics . 2008,第1期

机译：使用SVM自动检测外显子剪接增强剂（ESE）
2. Splice-shifting oligonucleotide (SSO) mediated blocking of an exonic splicing enhancer (ESE) created by the prevalent c.903+469T C MTRR mutation corrects splicing and restores enzyme activity in patient cells [J] . Palhais Bruno, Praestegaard Veronica S., Sabaratnam Rugivan, Nucleic Acids Research . 2015,第9期

机译：由普遍的c.903 + 469T> C MTRR突变产生的剪接移位寡核苷酸（SSO）介导的外显子剪接增强子（ESE）阻断可纠正剪接并恢复患者细胞中的酶活性
3. Splice-shifting oligonucleotide (SSO) mediated blocking of an exonic splicing enhancer (ESE) created by the prevalent c.903+469TC MTRR mutation corrects splicing and restores enzyme activity in patient cells [J] . Brage Storstein Andresen, Brian Fowler, Bruno Palhais, Nucleic acids research . 2015,第9期

机译：由普遍的c.903 + 469T> C MTRR突变产生的剪接移位寡核苷酸（SSO）介导的外显子剪接增强子（ESE）阻断可纠正剪接并恢复患者细胞中的酶活性
4. Therapeutic Modulation of DMD Splicing by Blocking Exonic Splicing Enhancer Sites with Antisense Oligonucleotides [C] . A.AARTSMA-RUS, A.A.M.JANSON, J.A.HEEMSKERK, Oligonucleotide Therapeutics Society . 2006

机译：用反义寡核苷酸阻断封锁剪接增强剂位点的DMD拼接治疗调节
5. Regulation of pre-mRNA splicing in mammalian cells: Identification and characterization of intronic and exonic silencers. [D] . Yu, Yang. 2007

机译：哺乳动物细胞中pre-mRNA剪接的调控：内含子和外显子沉默子的鉴定和表征。
6. Splice-shifting oligonucleotide (SSO) mediated blocking of an exonic splicing enhancer (ESE) created by the prevalent c.903+469TC MTRR mutation corrects splicing and restores enzyme activity in patient cells [O] . Bruno Palhais, Veronica S. Præstegaard, Rugivan Sabaratnam, 2015

机译：由普遍的c.903 + 469T C MTRR突变产生的剪接移位寡核苷酸（SSO）介导的外显子剪接增强子（ESE）阻断可纠正剪接并恢复患者细胞中的酶活性
7. Automatic detection of exonic splicing enhancers (ESEs) using SVMs [O] . Suhai Sándor, Gepperth Alexander, Mersch Britta, 2008

机译：使用SVM自动检测外显子剪接增强剂（ESE）

Automatic detection of exonic splicing enhancers (ESEs) using SVMs

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