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Interpolation based consensus clustering for gene expression time series

机译:基于插值的基因表达时间序列共识聚类

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摘要

BackgroundUnsupervised analyses such as clustering are the essential tools required to interpret time-series expression data from microarrays. Several clustering algorithms have been developed to analyze gene expression data. Early methods such as k-means, hierarchical clustering, and self-organizing maps are popular for their simplicity. However, because of noise and uncertainty of measurement, these common algorithms have low accuracy. Moreover, because gene expression is a temporal process, the relationship between successive time points should be considered in the analyses. In addition, biological processes are generally continuous; therefore, the datasets collected from time series experiments are often found to have an insufficient number of data points and, as a result, compensation for missing data can also be an issue.
机译:背景技术无监督分析(例如聚类分析)是解释微阵列中时间序列表达数据所需的基本工具。已经开发了几种聚类算法来分析基因表达数据。诸如k均值,层次聚类和自组织映射之类的早期方法因其简单性而广受欢迎。但是,由于噪声和测量的不确定性,这些常见算法的精度较低。此外,由于基因表达是一个时间过程,因此在分析中应考虑连续时间点之间的关系。另外,生物过程通常是连续的。因此,通常会发现从时间序列实验收集的数据集的数据点数量不足,因此,补偿丢失的数据也可能成为问题。

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