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Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane

机译:经血来源的干细胞接种的脱细胞人羊膜促进切除性伤口修复

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摘要

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3 × 104 cells/cm2 and implanted onto a rat’s 1.50 × 1.50 cm2 full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
机译:这是第一个证明经脱细胞人羊膜(DAM)进行经血来源的干细胞(MenSC)移植对促进皮肤切除伤口修复的功效的研究。将DAM用MenSCs播种,密度为3×10 4 / cells / cm 2 / cm3植入到大鼠1.50×1.50cm 2 完全厚度切除性伤口缺损。伤口闭合和组织病理学检查的结果表明,与DAM处理相比,接种MenSC的DAM可以显着改善伤口愈合。总而言之,我们的数据表明MenSCs可能是基于细胞的疗法再生皮肤损伤的潜在来源。

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