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首页> 美国卫生研究院文献>BioResearch Open Access >Aged Mice Repeatedly Injected with Plasma from Young Mice: A Survival Study
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Aged Mice Repeatedly Injected with Plasma from Young Mice: A Survival Study

机译：老年小鼠反复注射幼鼠血浆的存活研究

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摘要

It was reported using various biological models that the administration of blood factors from young animals to old animals could rejuvenate certain functions. To assess the anti-aging effect of young blood we tested the influence of repeated injections of plasma from young mice on the lifespan of aged mice. One group of 36 CBA/Ca female mice aged 10–12 months was treated by repeated injections of plasma from 2- to 4-month-old females (averaging 75–150 μL per injection, once intravenously and once intraperitoneally per week for 16 months). Their lifespan was compared to a control group that received saline injections. The median lifespan of mice from the control group was 27 months versus 26.4 months in plasma-treated group; the repeated injections of young plasma did not significantly impact either median or maximal lifespan.
机译：据报道，使用各种生物学模型，从年幼动物到年老动物的血液因子给药可以使某些功能恢复活力。为了评估年轻血液的抗衰老作用，我们测试了从年轻小鼠反复注射血浆对衰老小鼠寿命的影响。一组年龄在10至12个月的CBA / Ca雌性小鼠36只，通过从2至4个月大的雌性动物反复注射血浆（每次注射平均75-150μL，静脉内一次和每周一次腹膜内注射，共16个月）进行治疗）。将他们的寿命与接受盐水注射的对照组进行比较。对照组小鼠的平均寿命为27个月，而血浆治疗组为26.4个月。反复注射年轻血浆对中位寿命或最大寿命均无显着影响。

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