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首页> 美国卫生研究院文献>Biophysical Journal >The Diffusion of Oxygen Carbon Dioxide and Inert Gas in Flowing Blood
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The Diffusion of Oxygen Carbon Dioxide and Inert Gas in Flowing Blood

机译：流动的血液中氧气二氧化碳和惰性气体的扩散

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Measurements were made of exchange rates of oxygen, carbon dioxide, and krypton-85 with blood at 37.5°C. Gas transfer took place across a 1 mil silicone rubber membrane. The blood was in a rotating disk boundary layer flow, and the controlling resistance to transfer was the concentration boundary layer. Measured rates were compared with rates predicted from the equation of convective diffusion using velocities derived from the Navier-Stokes equations and diffusivities calculated from the theory for conduction in a heterogeneous medium. The measured absorption rate of krypton-85 was closely predicted by this model. Significant deposition of material onto the membrane surface, resulting in an increased transfer resistance, occurred in one experiment with blood previously used in a nonmembrane type artificial lung. The desorption rate of oxygen from blood at low Po21 was up to four times the corresponding transfer rate of inert gas. This effect is described somewhat conservatively by a local equilibrium form of the convective diffusion equation. The carbon dioxide transfer rate in blood near venous conditions was about twice that of inert gas, a rate significantly greater than predicted by the local equilibrium theory. It should be possible to apply these theoretical methods to predict exchange rates with blood flowing in systems of other geometries.
机译：在37.5°C下测量了氧气，二氧化碳和k 85与血液的交换速率。气体转移通过1密耳的硅橡胶膜进行。血液在转盘边界层中流动，对转移的控制阻力为浓度边界层。使用从Navier-Stokes方程得出的速度和从异质介质中的传导理论计算出的扩散率，将测得的速率与从对流扩散方程预测的速率进行比较。该模型密切预测了测得的k 85的吸收率。在先前使用非膜型人工肺中使用的血液的一项实验中，材料大量沉积在膜表面上，导致传输阻力增加。在低Po2 1 下，血液中氧气的解吸速率高达相应惰性气体传输速率的四倍。对流扩散方程的局部平衡形式在某种程度上保守地描述了这种效应。血液在接近静脉条件下的二氧化碳传输速率约为惰性气体的两倍，该速率大大高于局部平衡理论所预测的速率。应该有可能应用这些理论方法来预测与其他几何形状系统中血液流动的交换速率。

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