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首页> 美国卫生研究院文献>Biophysical Journal >Bending elastic modulus of red blood cell membrane derived from buckling instability in micropipet aspiration tests.
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Bending elastic modulus of red blood cell membrane derived from buckling instability in micropipet aspiration tests.

机译：微量吸液抽吸试验中屈曲不稳定性引起的红细胞膜弯曲弹性模量。

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摘要

Observation of cell membrane buckling and cell folding in micropipette aspiration experiments was used to evaluate the bending rigidity of the red blood cell membrane. The suction pressure required to buckle the membrane surface initially was found to be about one-half to two-thirds of the pressure that caused the cell to fold and move up the pipet. A simple analytical model for buckling of a membrane disk supported at inner and outer radii correlates well with the observed buckling pressures vs. pipet radii. The buckling pressure is predicted to increase in inverse proportion to the cube of the pipet radius; also, the buckling pressure depends inversely on the radial distance to the toroidal rim of the cell, normalized by the pipet radius. As such, the pressure required to buckle the membrane with 1 X 10(-4) cm diam pipet would be about four times greater than with a 2 X 10(-4) cm pipet. This is the behavior observed experimentally. Based on analysis of the observed buckling data, the membrane bending or curvature elastic modulus is calculated to be 1.8 X 10(-12) dyn-cm.
机译：在微量移液器抽吸实验中观察细胞膜屈曲和细胞折叠，以评估红细胞膜的弯曲刚度。最初发现使膜表面弯曲所需的抽吸压力约为导致细胞折叠并向上移向移液管的压力的一半至三分之二。用于支撑内外半径的膜片屈曲的简单分析模型与观察到的屈曲压力与吸管半径的关系很好。预测屈曲压力与吸管半径的立方成反比增加；同样，屈曲压力反比于到细胞的环形边缘的径向距离，该径向距离由吸管半径标准化。因此，用1 X 10（-4）cm直径的移液管弯曲膜所需的压力大约是用2 X 10（-4）cm的移液管弯曲的压力。这是实验观察到的行为。基于对观察到的屈曲数据的分析，膜的弯曲或曲率弹性模量计算为1.8 X 10（-12）dyn-cm。

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