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The use of dwell time cross-correlation functions to study single-ion channel gating kinetics.

机译：使用驻留时间互相关函数来研究单离子通道选通动力学。

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摘要

The derivation of cross-correlation functions from single-channel dwell (open and closed) times is described. Simulation of single-channel data for simple gating models, alongside theoretical treatment, is used to demonstrate the relationship of cross-correlation functions to underlying gating mechanisms. It is shown that time irreversibility of gating kinetics may be revealed in cross-correlation functions. Application of cross-correlation function analysis to data derived from the locust muscle glutamate receptor-channel provides evidence for multiple gateway states and time reversibility of gating. A model for the gating of this channel is used to show the effect of omission of brief channel events on cross-correlation functions.

机译：描述了从单通道驻留（打开和关闭）时间推导互相关函数。简单选通模型的单通道数据仿真以及理论处理，可用来证明互相关函数与基本选通机制之间的关系。结果表明，选通动力学的时间不可逆性可以在互相关函数中揭示。互相关函数分析应用于蝗虫谷氨酸受体通道的数据，为多种通道状态和门控时间可逆性提供了证据。使用此通道的门控模型来显示省略短暂通道事件对互相关函数的影响。

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期刊名称 Biophysical Journal
作者
F G Ball; C J Kerry; R L Ramsey; M S Sansom; P N Usherwood;
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作者单位

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年(卷),期 1988(54),2
年度 1988
页码 309–320
总页数 12
原文格式 PDF
正文语种
中图分类生物物理学;
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专利

1. Estimating transition rates in aggregated Markov models of ion channel gating with loops and with nearly equal dwell times [J] . Mirko Wagner, Steffen Michalek, Jens Timmer The Royal Society Proceedings B: Biological Sciences . 1999,第1431期

机译：估计具有循环且具有几乎相同的停留时间的离子通道门控的聚合马尔可夫模型的跃迁速率
2. Self-organized critical gating of ion channels: On the origin of long-term memory in dwell time series [J] . Brazhe AR, Maksimov GV Chaos . 2006,第3期

机译：自组织离子通道的临界门控：驻留时间序列中长期记忆的起源
3. Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR [J] . Nuriya Mukhtasimova, Corrie J.B. daCosta, Steven M. Sine The Journal of general physiology . 2016,第1期

机译：单通道停留时间的改善分辨率揭示了肌肉AChR的结合，引发和门控机制
4. On the Functional Relationship between Channel Holding Time and Cell Dwell Time in Mobile Cellular Networks [C] . Corral-Ruiz A.L.E., Rico-Páez A., Cruz-Pérez F.A., 2010 IEEE Global Telecommunications Conference . 2010

机译：移动蜂窝网络中信道保持时间与小区停留时间之间的函数关系
5. Computational Studies of the Concealed Gating Pathways and Electrophysiological Function of the Human Cardiac IKs Channel [D] . Ramasubramanian, Smiruthi 2018

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6. Estimating transition rates in aggregated Markov models of ion channel gating with loops and with nearly equal dwell times [O] . M. Wagner, S. Michalek, J. Timmer 1999

机译：估计具有循环且具有几乎相同的停留时间的离子通道门控聚合马尔可夫模型的跃迁速率
7. The use of dwell time cross-correlation functions to study single-ion channel gating kinetics. [O] . Ball, F G, Kerry, C J, Ramsey, R L, 1988

机译：使用驻留时间互相关函数来研究单离子通道选通动力学。
8. Analysis of Thermal Fluctuations in the Semiscale Tests to Determine Flow Transit Delay Times Using a Transfer Function Cross-Correlation Technique [R] . Raptis, A. C., Popper, G. F. 1977

机译：用传递函数互相关技术分析半导体测试中的热波动以确定流动延迟时间

The use of dwell time cross-correlation functions to study single-ion channel gating kinetics.

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