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首页> 美国卫生研究院文献>Biophysical Journal >Gel-liquid crystalline transition of some multilamellar lipid bilayers follows classical kinetics with a fractional dimensionality of approximately two.
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Gel-liquid crystalline transition of some multilamellar lipid bilayers follows classical kinetics with a fractional dimensionality of approximately two.

机译：一些多层脂质双层的凝胶-液晶转变遵循经典动力学其分数维约为2。

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摘要

The relaxation kinetics of the gel-liquid crystalline transition of phosphatidylcholine (DC14PC, DC16PC, and DC18PC) multilamellar vesicles have been examined using volume-perturbation calorimetry. The time-dependent temperature and pressure changes associated with a periodic volume perturbation are monitored in real time. Data collected in the time domain are transformed to the frequency domain using Fourier series representations of the perturbation and response functions. Because a very small perturbation is imposed during the experiment, linear response theory is suitable for analysis of the relaxation process. The Laplace transform of the classical Kolmogorov-Avrami relation of transition kinetics is used to describe the dynamic response in the frequency domain. For DC14PC and DC16PC, the relaxation process is better fit with an effective dimensionality of n = 2 rather than n = 1. For DC18PC, we estimate that an effective dimensionality of approximately 1.5 will best fit the data. These results indicate that the gel-liquid crystalline transition of these lipid bilayers follows the classical Kolmogorov-Avrami kinetic model with an effective dimensionality greater than 1 and the assumption of simple exponential decay (n = 1) commonly used in data analysis may not always be valid for lipid transitions. Insofar as the dimensionality of the relaxation reflects the geometry of fluctuating lipid clusters, this parameter may be useful in connecting experimental thermodynamic and kinetic results with those obtained from Monte Carlo simulations.
机译：磷脂酰胆碱（DC14PC，DC16PC和DC18PC）多层囊泡的凝胶-液晶转变的弛豫动力学已使用体积扰动量热法进行了研究。与时间相关的温度和压力的变化与周期性的体积扰动有关，可以实时监控。使用微扰和响应函数的傅立叶级数表示，将时域中收集的数据转换为频域。由于在实验过程中会产生很小的扰动，因此线性响应理论适用于弛豫过程的分析。经典的跃迁动力学的Kolmogorov-Avrami关系的拉普拉斯变换用于描述频域中的动态响应。对于DC14PC和DC16PC，松弛过程更适合于n = 2的有效尺寸，而不是n =1。对于DC18PC，我们估计大约1.5的有效尺寸将最适合数据。这些结果表明，这些脂质双层的凝胶-液晶转变遵循经典的Kolmogorov-Avrami动力学模型，有效尺寸大于1，并且数据分析中常用的简单指数衰减（n = 1）的假设可能并不总是对脂质过渡有效。只要弛豫的维数反映了波动的脂质簇的几何形状，该参数对于将实验热力学和动力学结果与从蒙特卡洛模拟获得的结果联系起来可能是有用的。

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