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首页> 美国卫生研究院文献>Biophysical Journal >Direct determination of hydration in the interdigitated and ripple phases of dihexadecylphosphatidylcholine: hydration of a hydrophobic cavity at the membrane/water interface.
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Direct determination of hydration in the interdigitated and ripple phases of dihexadecylphosphatidylcholine: hydration of a hydrophobic cavity at the membrane/water interface.

机译：直接测定二十六烷基磷脂酰胆碱的交叉相和波纹相中的水合：膜/水界面处疏水腔的水合。

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摘要

Hydrophobic cavities at the membrane/water interface are stably expressed in interdigitated membranes. The nonsolvent water associated with 1,2-di-O-hexadecyl-sn-glycero-3-phosphocholine (Hxdc(2)GroPCho) in the interdigitated (L(beta)I) and ripple (P(beta')) states and with its ester analogue 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine (Pam(2)PtdCho) in the gel (L(beta')) and P(beta') states are determined directly. In the L(beta)I state at lower temperatures (4-20 degrees C), 16-18 water molecules per phospholipid are bound, consistent with water-filled cavities and hydrated headgroups. At 28 degrees C, the nonsolvent water decreases to 12, consistent with a reduction of the cavity depth by 0.34 nm due to increased chain interpenetration. This geometric lability may be a common feature of hydrophobic cavities. Only 5.4 waters are bound in the noninterdigitated P(beta') (40 degrees C), whereas the ester bound 8.1 waters in its P(beta') (37 degrees C), a difference of about one water per ester carbonyl. The relative dehydration of the ether linkage is consistent with it promoting more densely packed structures, which in turn, accounts for its ability to interdigitate.
机译：膜/水界面处的疏水腔在指状膜中稳定表达。与1,2-二-O-十六烷基-sn-甘油-3-磷酸胆碱（Hxdc（2）GroPCho）关联的非溶剂水处于叉指状态（LβI）和波纹状态（P（beta'））和用其酯类似物1、2-二棕榈酰-sn-甘油-3-磷酸胆碱（Pam（2）PtdCho）在凝胶中（L（beta'））和P（beta'）状态直接测定。在较低温度（4-20℃）下的LβI状态，每个磷脂结合16-18个水分子，这与充满水的空腔和水合的头基一致。在28摄氏度时，非溶剂水减少至12，这与由于链互穿度增加而导致的腔深度减少0.34 nm相一致。这种几何上的不稳定性可能是疏水腔的共同特征。在非交指的P（β'）（40摄氏度）中仅结合了5.4水，而酯在其P（β'）（37摄氏度）中结合了8.1水，每个酯羰基相差约一水。醚键的相对脱水与其促进更紧密堆积的结构是一致的，这反过来又说明了其相互交叉的能力。

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