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Poly-L-Lysine-Induced Morphology Changes in Mixed Anionic/Zwitterionic and Neat Zwitterionic-Supported Phospholipid Bilayers

机译：聚-L-赖氨酸诱导的阴离子/两性离子和纯两性离子支持的磷脂双层膜的形态变化

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摘要

Poly-L-lysine-induced morphological changes in liquid phase supported bilayers consisting of mixed anionic/zwitterionic and neat zwitterionic headgroup phospholipids were studied with atomic force microscopy and epifluorescence microscopy. Results obtained from these studies indicate that poly-L-lysine can induce domains, defects, and aggregate structures on both mixed bilayers and strictly zwitterionic bilayers. The structures formed on liquid phase supported bilayers were observed to be immobile from a timescale of 50 ms to several minutes. We propose that poly-L-lysine of sufficient length interacts with the mica substrate and phospholipids to create the stationary structures noted.

机译：用原子力显微镜和落射荧光显微镜研究了聚-L-赖氨酸在由阴离子/两性离子和纯两性离子头基混合磷脂组成的液相支撑双层中诱导的形态变化。从这些研究中获得的结果表明，聚-L-赖氨酸可以在混合双层和严格两性离子双层上诱导畴，缺陷和聚集结构。观察到在液相负载的双层上形成的结构在50ms到几分钟的时间范围内是不动的。我们提出足够长的聚-L-赖氨酸与云母底物和磷脂相互作用以产生所述的固定结构。

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期刊名称 Biophysical Journal
作者
Tighe A. Spurlin; Andrew A. Gewirth;
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年(卷),期 2006(91),8
年度 2006
页码 2919–2927
总页数 9
原文格式 PDF
正文语种
中图分类生物物理学;
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专利

1. Poly-L-lysine-induced morphology changes in mixed anionic/zwitterionic and neat zwitterionic-supported phospholipid bilayers. [J] . Spurlin TA, Gewirth AA Biophysical Journal . 2006,第8期

机译：在混合的阴离子/两性离子和纯两性离子负载的磷脂双层中，聚-L-赖氨酸诱导的形态变化。
2. Partitioning of 1-pyrenesulfonate into zwitterionic and mixed zwitterionic/anionic fluid phospholipid bilayers [J] . Manuel M, Martins J Chemistry and Physics of Lipids . 2008,第2期

机译：1-吡咯烷磺酸酯分配至两性离子和混合的两性离子/阴离子液体磷脂双层
3. Influence of Monovalent Cation Size on Nanodomain Formation in Anionic-Zwitterionic Mixed Bilayers [J] . Ganesan Sai J., Xu Hongcheng, Matysiak Silvina The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2017,第4期

机译：单价阳离子大小对阴离子 - 两性离子混合双层纳米域形成的影响
4. Computational modeling of anionic and zwitterionic lipid bilayers for investigating surface activities of bioactive molecules [C] . Jutarat Pimthon, Regine Willumeit, Andreas Lendlein, Symposium HH on Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging . 2009

机译：阴离子和两性离子脂双层用于研究生物活性分子表面活性的计算模拟
5. Chapter 1: (I) Use of chain-modified phospholipids to determine water content of bilayers. (II) Ion transport across bilayers of chain-modified phospholipids. Chapter 2: Synthesis, catalytic properties of and studies toward electron transport by copper-complexed lipids. [D] . Aikens, Patricia Ann Elizabeth. 1990

机译：第1章：（I）使用链修饰的磷脂测定双层的水含量。（II）跨链修饰的磷脂的双层的离子运输。第2章：铜络合物脂质的合成，催化性能以及对电子的研究。
6. Molecular Dynamics Simulations of Mixed Acidic/Zwitterionic Phospholipid Bilayers [O] . Torben Broemstrup, Nathalie Reuter 2010

机译：酸性/两性离子混合磷脂双层分子动力学模拟
7. Poly-L-Lysine-Induced Morphology Changes in Mixed Anionic/Zwitterionic and Neat Zwitterionic-Supported Phospholipid Bilayers [O] . Spurlin, Tighe A., Gewirth, Andrew A. 2006

机译：聚-L-赖氨酸诱导的阴离子/两性离子和纯两性离子支持的磷脂双层膜的形态变化

Poly-L-Lysine-Induced Morphology Changes in Mixed Anionic/Zwitterionic and Neat Zwitterionic-Supported Phospholipid Bilayers

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