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首页> 美国卫生研究院文献>Biomicrofluidics >Pressure driven spinning: A multifaceted approach for preparing nanoscaled functionalized fibers scaffolds and membranes with advanced materials
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Pressure driven spinning: A multifaceted approach for preparing nanoscaled functionalized fibers scaffolds and membranes with advanced materials

机译：压力驱动纺丝：采用先进材料制备纳米级功能化纤维支架和膜的多方面方法

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Electrospinning, a flexible jet-based fiber, scaffold, and membrane fabrication approach, has been elucidated as having significance to the heath sciences. Its capabilities have been most impressive as it possesses the ability to spin composite fibers ranging from the nanometer to the micrometer scale. Nonetheless, electrospinning has limitations and hazards, negating its wider exploration, for example, the inability to handle highly conducting suspensions, to its hazardous high voltage. Hence, to date electrospinning has undergone an exhaustive research regime to a point of cliché. Thus, in the work reported herein we unveil a competing technique to electrospinning, which has overcome the above limitations and hazards yet comparable in capabilities. The fiber preparation approach unearthed herein is referred to as “pressure driven spinning (PDS).” The driving mechanism exploited in this fiber spinning process is the pressurized by-pass flow. This mechanism allows the drawing of either micro- or nanosized fibers while processing polymeric suspensions containing a wide range of advanced materials spanning structural, functional, and biological entities. Similar to electrospinning if the collection time of these continuous formed fibers is varied, composite scaffolds and membranes are generated. In keeping with our interests, multicompositional structural entities such as these could have several applications in biology and medicine, for example, ranging from the development of three-dimensional cultures (including disease models) to the development of synthetic tissues and organ structures to advanced approaches for controlled and targeted therapeutics.
机译：静电纺丝是一种灵活的基于喷射的纤维，支架和膜的制造方法，已被阐明对健康科学具有重要意义。它的能力令人印象深刻，因为它具有纺制从纳米级到微米级范围的复合纤维的能力。但是，静电纺丝具有局限性和危害性，因此无法进行更广泛的探索，例如无法将高导电性的悬浮物处理成危险的高压。因此，迄今为止，静电纺丝已经经历了详尽的研究，达到陈词滥调的程度。因此，在本文报道的工作中，我们揭示了一种竞争的电纺技术，该技术克服了上述局限性和危害，但性能却相当。本文中出土的纤维制备方法称为“压力驱动纺丝（PDS）”。在这种纤维纺丝工艺中使用的驱动机制是加压的旁通气流。这种机理允许在处理包含多种先进材料的聚合物悬浮液时，可拉伸微米或纳米级纤维，这些材料涵盖结构，功能和生物学实体。如果改变这些连续形成的纤维的收集时间，则类似于静电纺丝，会生成复合支架和膜。为了符合我们的兴趣，诸如此类的多结构结构实体可能在生物学和医学中具有多种应用，例如，从三维文化的发展（包括疾病模型）到合成组织和器官结构的发展，再到先进的方法用于受控和靶向治疗。

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