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首页> 美国卫生研究院文献>Biomicrofluidics >Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet
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Simultaneous diamagnetic and magnetic particle trapping in ferrofluid microflows via a single permanent magnet

机译：通过单个永磁体同时捕获铁磁微流中的反磁性和磁性粒子

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摘要

Trapping and preconcentrating particles and cells for enhanced detection and analysis are often essential in many chemical and biological applications. Existing methods for diamagnetic particle trapping require the placement of one or multiple pairs of magnets nearby the particle flowing channel. The strong attractive or repulsive force between the magnets makes it difficult to align and place them close enough to the channel, which not only complicates the device fabrication but also restricts the particle trapping performance. This work demonstrates for the first time the use of a single permanent magnet to simultaneously trap diamagnetic and magnetic particles in ferrofluid flows through a T-shaped microchannel. The two types of particles are preconcentrated to distinct locations of the T-junction due to the induced negative and positive magnetophoretic motions, respectively. Moreover, they can be sequentially released from their respective trapping spots by simply increasing the ferrofluid flow rate. In addition, a three-dimensional numerical model is developed, which predicts with a reasonable agreement the trajectories of diamagnetic and magnetic particles as well as the buildup of ferrofluid nanoparticles.
机译：在许多化学和生物学应用中，捕获和预浓缩颗粒和细胞以进行增强的检测和分析通常是必不可少的。现有的用于反磁性粒子捕获的方法需要在粒子流动通道附近放置一对或多对磁体。磁体之间的强大吸引力或排斥力使其难以对准并足够靠近通道放置，这不仅使设备制造复杂化，而且限制了颗粒捕获性能。这项工作首次证明了使用单个永磁体同时捕获流过T形微通道的铁磁流体中的反磁性和磁性粒子。分别由于感应的负磁运动和正磁运动，两种类型的粒子被预集中到T型结的不同位置。而且，通过简单地增加铁磁流体的流速就可以从它们各自的捕获点顺序地释放它们。此外，建立了一个三维数值模型，该模型以合理的一致性预测了反磁性和磁性粒子的轨迹以及铁磁纳米粒子的堆积。

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