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An optofluidic system with volume measurement and surface plasmon resonancesensor for continuous glucose monitoring

机译：具有体积测量和表面等离子体共振的光流体系统连续葡萄糖监测传感器

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摘要

The traditional technology of glucose monitoring is painful and invasive because of the frequent blood collection. Nowadays, the enzyme electrode sensor is mainly used for continuous glucose monitoring in clinic, but it has inherent disadvantages of significant signal drift of current due to bioelectricity in body and the missing of hypoglycemia resulting from the irreversible consumption of glucose at the process of enzyme catalytic reaction. Interstitial fluid (ISF) transdermal extraction can be nearly unsensible which effectively reduces the pain caused by invasive detection so that it may provide a new way to monitor glucose. MEMS technology has been used to produce devices for transdermal ISF extraction, but there is a lack of on-chip ISF volume measurement capabilities, which are required to compensate skin permeability variations. This paper presents a lab-on-a-chip system for ISF transdermal extraction, ISF volume measurement, and optical glucose sensing towards the application of continuous glucose monitoring. The device significantly incorporates a MEMS volume sensor, which measures extracted ISF volume via conductance monitoring, and integrates a fiber-opticsurface plasmonresonance sensor to measure glucose concentration in microchannel. Thefiber-based technique provides an excellent approach to overcome the above two drawbacksof the enzymeelectrode basedglucose sensing. Six different volumes were tested, and the standard deviation of everysample is less than 0.05 μl, The resonance wavelength moves from549.081 nm to 592.914 nm while the concentration ranges from 0 to 200 mg/dl. Thefeasibility of the single-chip device for accurate and continuous monitoring ofsubcutaneous ISF glucose concentrations is verified.
机译：由于频繁的血液采集，传统的葡萄糖监测技术令人痛苦且具有侵入性。如今，酶电极传感器主要用于临床中的连续葡萄糖监测，但其固有的缺点是由于体内生物电导致电流信号明显漂移，以及由于酶催化过程中葡萄糖不可逆消耗而导致的低血糖缺失反应。间质液（ISF）透皮提取可能几乎是不明智的，从而有效地减少了有创检测所引起的疼痛，因此它可以提供一种监测葡萄糖的新方法。 MEMS技术已被用于生产用于经皮ISF提取的设备，但是缺少片上ISF体积测量功能，而这是补偿皮肤渗透性变化所必需的。本文介绍了一种用于ISF透皮提取，ISF体积测量和光学葡萄糖传感的芯片实验室系统，以实现连续葡萄糖监测的应用。该设备显着集成了MEMS体积传感器，该传感器通过电导监测来测量提取的ISF体积，并集成了光纤表面等离激元共振传感器来测量微通道中的葡萄糖浓度。的基于纤维的技术提供了一种克服上述两个缺点的极好的方法酶的基于电极葡萄糖感测。测试了六个不同的体积，每个体积的标准偏差样品小于0.05μl，共振波长从549.081 nm至592.914 nm，浓度范围为0至200 mg / dl。的单芯片器件用于精确连续监控器件的可行性皮下ISF葡萄糖浓度得到验证。

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