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首页> 美国卫生研究院文献>Biomedical Optics Express >Design of high-performance adaptive objective lens with large optical depth scanning range for ultrabroad near infrared microscopic imaging
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Design of high-performance adaptive objective lens with large optical depth scanning range for ultrabroad near infrared microscopic imaging

机译：具有大光学深度扫描范围的高性能自适应物镜用于超宽近红外显微成像

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We report on the theory and design of adaptive objective lens for ultra broadband near infrared light imaging with large dynamic optical depth scanning range by using an embedded tunable lens, which can find wide applications in deep tissue biomedical imaging systems, such as confocal microscope, optical coherence tomography (OCT), two-photon microscopy, etc., both in vivo and ex vivo. This design is based on, but not limited to, a home-made prototype of liquid-filled membrane lens with a clear aperture of 8mm and the thickness of 2.55mm ~3.18mm. It is beneficial to have an adaptive objective lens which allows an extended depth scanning range larger than the focal length zoom range, since this will keep the magnification of the whole system, numerical aperture (NA), field of view (FOV), and resolution more consistent. To achieve this goal, a systematic theory is presented, for the first time to our acknowledgment, by inserting the varifocal lens in between a front and a back solid lens group. The designed objective has a compact size (10mm-diameter and 15mm-length), ultrabroad working bandwidth (760nm - 920nm), a large depth scanning range (7.36mm in air) — 1.533 times of focal length zoom range (4.8mm in air), and a FOV around 1mm × 1mm. Diffraction-limited performance can be achieved within this ultrabroad bandwidth through all the scanning depth (the resolution is 2.22 μm - 2.81 μm, calculated at the wavelength of 800nm with the NA of 0.214 - 0.171). The chromatic focal shift value is within the depth of focus (field). The chromatic difference in distortion is nearly zero and the maximum distortion is less than 0.05%.
机译：我们报告了通过使用嵌入式可调透镜对具有大动态光学深度扫描范围的超宽带近红外成像进行自适应物镜的理论和设计，该透镜可在共聚焦显微镜，光学显微镜等深部组织生物医学成像系统中找到广泛的应用体内和体外的相干层析成像（OCT），双光子显微镜等。该设计基于但不限于透明孔径为8mm，厚度为2.55mm〜3.18mm的液体填充薄膜透镜的原型。自适应物镜的扩展深度扫描范围大于焦距变焦范围是有利的，因为这将保持整个系统的放大倍率，数值孔径（NA），视场（FOV）和分辨率更一致。为实现这一目标，我们首次通过将变焦镜头插入前，后实心镜片组之间，提出了系统的理论，这对我们来说是公认的。设计的物镜具有紧凑的尺寸（直径10mm和长度15mm），超宽工作带宽（760nm-920nm），较大的深度扫描范围（空中7.36mm）—焦距变焦范围（空中4.8mm）的1.533倍），且FOV约为1mm×1mm。在整个扫描深度范围内，均可在此超宽带带宽内实现衍射极限性能（分辨率为2.22μm-2.81μm，在800nm波长下计算，NA为0.214-0.171）。彩色焦点偏移值在焦点深度（场）内。失真的色差几乎为零，最大失真小于0.05％。

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