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Relation between speckle decorrelation and optical phase conjugation (OPC)-based turbidity suppression through dynamic scattering media: a study on in vivo mouse skin

机译:动态散射介质抑制斑点去相关与基于光相共轭(OPC)的浊度之间的关系:体内小鼠皮肤的研究

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摘要

Light scattering in biological tissue significantly limits the accessible depth for localized optical interrogation and deep-tissue optical imaging. This challenge can be overcome by exploiting the time-reversal property of optical phase conjugation (OPC) to reverse multiple scattering events or suppress turbidity. However, in living tissue, scatterers are highly movable and the movement can disrupt time-reversal symmetry when there is a latency in the OPC playback. In this paper, we show that the motion-induced degradation of the OPC turbidity-suppression effect through a dynamic scattering medium shares the same decorrelation time constant as that determined from speckle intensity autocorrelation – a popular conventional measure of scatterer movement. We investigated this decorrelation characteristic time through a 1.5-mm-thick dorsal skin flap of a living mouse and found that it ranges from 50 ms to 2.5 s depending on the level of immobilization. This study provides information on relevant time scales for applying OPC to living tissues.
机译:生物组织中的光散射极大地限制了局部光学询问和深部组织光学成像的可接近深度。通过利用光学相位共轭(OPC)的时间反转特性来反转多个散射事件或抑制浊度,可以克服这一挑战。但是,在活体组织中,散射体是高度可移动的,并且当OPC播放出现延迟时,移动会破坏时间反转对称性。在本文中,我们表明,通过动态散射介质通过运动引起的OPC浊度抑制效果的退化与通过散斑强度自相关确定的去相关时间常数具有相同的去相关时间常数,散斑强度自相关是一种常用的散射运动常规度量。我们通过一只活着的老鼠的1.5毫米厚的背侧皮瓣研究了这个去相关特征时间,发现它的固定范围从50毫秒到2.5 s不等。这项研究提供了有关将OPC应用于活组织的相关时标的信息。

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