• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Biomedical Optics Express >Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions
【2h】

Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions

机译：带有波前无传感器自适应光学器件的广域视网膜光学相干断层扫描可增强目标区域的成像

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (<25°) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to calculate the optimization metric. Our WSAO approach with a 3 mm beam diameter permitted primarily low- but also high- order peripheral wavefront correction in less than 10 seconds. In preliminary imaging studies in five normal human subjects, we quantified statistically significant changes with WSAO correction, corresponding to a 10.4% improvement in average pixel brightness (signal) and 7.0% improvement in high frequency content (resolution) when visualizing 1 mm (~3.5°) B-scans of the peripheral (>23°) retina. We demonstrated the ability of our WF-OCT system to acquire non wavefront-corrected wide-field images rapidly, which could then be used to locate regions of interest, zoom into targeted features, and visualize the same region at different time points. A pilot clinical study was conducted on seven healthy volunteers and two subjects with prodromal Alzheimer’s disease which illustrated the capability to image Drusen-like pathologies as far as 32.5° from the fovea in un-averaged volume scans. This work suggests that the proposed combination of WF-OCT and WSAO may find applications in the diagnosis and treatment of ocular, and potentially neurodegenerative, diseases of the peripheral retina, including diabetes and Alzheimer’s disease.
机译：人眼的周围视网膜为评估和监测眼部疾病提供了独特的机会。我们已经开发了一种新颖的广域（> 70°）光学相干断层扫描系统（WF-OCT），该系统配备了波前无传感器自适应光学系统（WSAO），可增强周边视网膜中较小的目标区域（<25°）的可视化能力。我们使用原始光谱干涉图来计算优化指标，从而以单个OCT B扫描（〜20 ms）的速度迭代WSAO算法。我们的WSAO方法的光束直径为3 mm，可以在不到10秒的时间内进行低阶和高阶周边波前校正。在五个正常人的初步成像研究中，我们用WSAO校正对统计学上的显着变化进行了量化，当可视化1毫米（〜3.5）时，平均像素亮度（信号）提高了10.4％，高频含量（分辨率）提高了7.0％。 °）对周围（> 23°）视网膜进行B扫描。我们展示了WF-OCT系统能够快速获取未经波前校正的宽视场图像的功能，然后可以将其用于定位感兴趣的区域，放大目标特征并在不同的时间点可视化相同的区域。一项针对7名健康志愿者和2名患有前驱性阿尔茨海默氏病的受试者进行了一项临床试验研究，该研究表明，在非平均体积扫描中，能够将距中心凹32.5°的类疣状病理成像。这项工作表明，WF-OCT和WSAO的拟议组合可能在眼周和潜在的神经退行性视网膜疾病（包括糖尿病和阿尔茨海默氏病）的诊断和治疗中找到应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号