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Reference-free determination of tissue absorption coefficient by modulation transfer function characterization in spatial frequency domain

机译:通过空频域中的调制传递函数表征无参考确定组织吸收系数

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摘要

BackgroundSpatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials. To address this problem, we present a reference-free SFD determination of absorption coefficient that is based on the modulation transfer function (MTF) characterization.
机译:背景技术空间频域(SFD)测量允许对组织光学特性进行快速和非接触式广域成像,因此已成为评估皮肤疾病的光动力疗法过程中生理参数和治疗反应的潜在工具。常规的SFD测量需要在与测试用例相同的实验场景下进行参考测量,以校准实际测量值与模型预测之间的不匹配。由于不同组织,器官和患者之间的个体物理和几何差异,因此在临床试验中可能无法获得理想的参考测量值。为了解决这个问题,我们提出了基于调制传递函数(MTF)表征的吸收系数的无参考SFD测定。

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