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Stability study of docetaxel solution (0.9 saline) using Non-PVC and PVC tubes for intravenous administration

机译：使用非PVC和PVC管静脉注射多西紫杉醇溶液（0.9％盐水）的稳定性研究

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摘要

BackgroundDi-2-ethylhexyl phthalate (DEHP) are added to poly(vinyl chloride)(PVC) infusion tubes as a plasticizer to ensure tube flexibility. In addition to previously reported disadvantages of DEHP, released DEHP molecules from PVC tubes can easily interact with surfactants in anticancer drug solutions (i.e., polysorbate 80 for Taxotere®-Inj) and reduce the solubility of docetaxel in aqueous solution during anticancer drug administration.

机译：背景技术邻苯二甲酸二-2-乙基己酯（DEHP）作为增塑剂添加到聚氯乙烯（PVC）输液管中，以确保管的柔韧性。除了先前报道的DEHP的缺点外，PVC管中释放的DEHP分子还可以轻松地与抗癌药溶液中的表面活性剂相互作用（例如，Taxotere®-Inj的聚山梨酯80），并降低了抗癌药给药过程中多西紫杉醇在水溶液中的溶解度。

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期刊名称 Biomaterials Research
作者
Kang Hoon Park; Dong June Chung;
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作者单位

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年(卷),期 2015(19),-1
年度 2015
页码 2
总页数 5
原文格式 PDF
正文语种
中图分类生物学;
关键词
Docetaxel Infusion tube Non-PVC Di-2-ethylhexyl phthalate(DEHP) Polysorbate 80;

机译：多西紫杉醇;输液管;非PVC;邻苯二甲酸二-2-乙基己酯（DEHP）;聚山梨酯80;

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专利

1. Stability study of docetaxel solution (0.9%, saline) using Non-PVC and PVC tubes for intravenous administration [J] . Kang Hoon Park, Dong June Chung Biomaterials Research . 2015,第1期

机译：使用非PVC和PVC管静脉注射多西紫杉醇溶液（0.9％，盐水）的稳定性研究
2. Stability of Propofol Medium Chain Triglyceride/Long Chain Triglyceride (MCT/LCT) in 0.9% NaCI Solution with CRYOVAC? Non-PVC Soft Bag Containers [J] . LI-JUE WEI, WEN-BANG CHANG, CHUN-HUNG LIN, Journal of food and drug analysis . 2013,第1期

机译：使用CRYOVAC在0.9％NaCl溶液中异丙酚中链甘油三酸酯/长链甘油三酸酯（MCT / LCT）的稳定性？非PVC软袋容器
3. Changes in body composition, hematologic parameters, and serum biochemistry after rapid intravenous infusion or oral intake of 2 liters of 0.9% saline solution in young healthy volunteers: randomized crossover study. [J] . José E de Aguilar-Nascimento, Ana C Valente, Sergio S Oliveira, World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons . 2012,第12期

机译：年轻健康志愿者快速静脉输注或口服2升0.9％盐溶液后身体成分，血液学参数和血清生化的变化：随机交叉研究。
4. Influence of pH-variation with two different acids of 0.9 saline solution on the corrosion behaviour of two experimental dental CoCr alloys with same PRE [C] . C. Schille, G. Hausch, E. Schweizer, European Corrosion Congress . 2017

机译：PH变异对0.9％盐水溶液两种不同酸的影响对同一前的两种实验牙科合金的腐蚀行为
5. Experimental studies of pulsatile flows through compliant tubes undergoing forced wall motion: Applications to hemodynamics and stability. [D] . Sturgeon, Victoria Carolyn Savedge. 2007

机译：流经顺应管的顺应性管的搏动性流动的实验研究：血液动力学和稳定性的应用
6. Stability study of dezocine in 0.9 sodium chloride solutions for patient-controlled analgesia administration [O] . Bao-Xia Fang, Lin-Hai Wang, Hui-Min Liu, -1

机译：0.9％氯化钠溶液中地佐辛在患者控制镇痛中的稳定性研究
7. Stability study of docetaxel solution (0.9, saline) using Non-PVC and PVC tubes for intravenous administration [O] . 2015

机译：使用非PVC和PVC管静脉注射多西紫杉醇溶液（0.9％，盐水）的稳定性研究

Stability study of docetaxel solution (0.9 saline) using Non-PVC and PVC tubes for intravenous administration

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