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The influence of operating parameters on the drug release and antibacterial performances of alginate fibrous dressings prepared by wet spinning

机译：操作参数对湿法纺丝藻酸盐纤维敷料的释药和抗菌性能的影响

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摘要

Wet spinning was used to manufacture fibrous alginate hydrogel wound dressings. Samples manufactured using varied operating parameters (decreased air pressure and calcium concentration or increased nozzle diameter and alginate concentration) were compared with the control samples. The changes in the fiber size, Young’s modulus, swelling ratio, fetal bovine serum (BSA) release efficacy, water vapor transmission rate (WVTR) and bacterial inhibition potential due to alterations of the operating parameters were measured. The samples manufactured using altered operating parameters had larger fiber sizes (p < 0.05) and lower Young’s moduli (p < 0.05). The changes in swelling ratios, BSA release efficacies, WVTR and bacterial inhibition potential showed a significant dependence on the degree of calcium crosslinking of the hydrogel and on how tightly the fibers were bound with one another. By manipulating the operating parameters in the wet-spinning system, wound dressings with different properties were successfully made.
机译：湿法纺丝用于制造纤维状藻酸盐水凝胶伤口敷料。将使用各种操作参数（降低的气压和钙浓度或增加的喷嘴直径和藻酸盐浓度）制造的样品与对照样品进行比较。由于操作参数的变化，测量了纤维尺寸，杨氏模量，溶胀率，胎牛血清（BSA）释放功效，水蒸气透过率（WVTR）和细菌抑制潜能的变化。使用改变的操作参数制造的样品具有较大的纤维尺寸（p <0.05）和较低的杨氏模量（p <0.05）。溶胀率，BSA释放效率，WVTR和细菌抑制潜能的变化显示出对水凝胶钙交联度以及纤维彼此紧密结合程度的显着依赖。通过控制湿纺系统中的操作参数，成功制备了具有不同性能的伤口敷料。

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