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首页> 美国卫生研究院文献>Journal of Pharmaceutical Analysis >Trace analysis of mefenamic acid in human serum and pharmaceutical wastewater samples after pre-concentration with Ni–Al layered double hydroxide nano-particles
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Trace analysis of mefenamic acid in human serum and pharmaceutical wastewater samples after pre-concentration with Ni–Al layered double hydroxide nano-particles

机译：镍铝层状双氢氧化物纳米粒子预浓缩后的人体血清和制药废水样品中的甲芬那酸的痕量分析

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摘要

In this work, the nickel–aluminum layered double hydroxide (Ni–Al LDH) with nitrate interlayer anion was synthesized and used as a solid phase extraction sorbent for the selective separation and pre-concentration of mefenamic acid prior to quantification by UV detection at λmax=286 nm. Extraction procedure is based on the adsorption of mefenamate anions on the Ni–Al(NO3−) LDH and/or their exchange with LDH interlayer NO3− anions. The effects of several parameters such as cations and interlayer anions type in LDH structure, pH, sample flow rate, elution conditions, amount of nano-sorbent and co-existing ions on the extraction were investigated and optimized. Under the optimum conditions, the calibration graph was linear within the range of 2–1000 µg/L with a correlation coefficient of 0.9995. The limit of detection and relative standard deviation were 0.6 µg/L and 0.84% (30 µg/L, n=6), respectively. The presented method was successfully applied to determine of mefenamic acid in human serum and pharmaceutical wastewater samples.
机译：在这项工作中，合成了具有硝酸盐层间阴离子的镍铝层状双氢氧化物（Ni-Al LDH），并用作固相萃取吸附剂，用于选择性分离和预浓缩甲芬那酸，然后通过λmax的UV检测进行定量= 286纳米萃取过程基于甲芬酸根阴离子在Ni–Al（NO3 -）LDH上的吸附和/或它们与LDH中间层NO3 -阴离子的交换。研究并优化了LDH结构中阳离子和层间阴离子类型，pH，样品流速，洗脱条件，纳米吸附剂和共存离子的数量等参数对萃取的影响。在最佳条件下，校准曲线在2–1000 µg / L范围内呈线性，相关系数为0.9995。检出限和相对标准偏差分别为0.6 µg / L和0.84％（30 µg / L，n = 6）。该方法成功地用于测定人血清和制药废水样品中的甲芬那酸。

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