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首页> 美国卫生研究院文献>Biological Research >Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.
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Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don.

机译：分离的粗制皂苷和Rumex hastatus D. Don的不同馏分的抗肿瘤和抗血管生成潜力。

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BackgroundCancer, being the foremost challenge of the modern era and the focus of world-class investigators, gargantuan research is in progress worldwide to explore novel therapeutic for its management. The exploitation of natural sources has been proven to be an excellent approach to treat or minify the excessive angiogenesis and proliferation of cells. Similarly, based the ethnomedicinal uses and literature survey, the current study is designed to explore the anti-tumor and anti-angiogenic potentials of Rumexhastatus. Anti-tumor and anti-angiogenic activities were carried out using potato-disc model and chorioallantoic membrane (CAM) assay respectively. Moreover, R. hastatus was also assessed for antibacterial activity against Agrobacteriumtumefaciens (tumor causing bacterial strain). The positive controls used in anti-tumor, anti-angiogenic and antibacterial activities were vincristine sulphate, dexamethasone and cefotaxime respectively.
机译：背景技术癌症是现代社会面临的最严峻挑战，也是世界一流研究者的关注焦点，全球范围内正在进行庞大的研究，以探索对其进行治疗的新型疗法。事实证明，开发天然来源是治疗或减少过度血管生成和细胞增殖的极佳方法。同样，根据人种医学用途和文献调查，本研究旨在探索Rumexhastatus的抗肿瘤和抗血管生成潜力。分别使用马铃薯-盘片模型和绒膜尿囊膜（CAM）测定法进行抗肿瘤和抗血管生成活性。此外，还评估了R. hastatus对根癌农杆菌（引起肿瘤的细菌菌株）的抗菌活性。用于抗肿瘤，抗血管生成和抗菌活性的阳性对照分别是硫酸长春新碱，地塞米松和头孢噻肟。

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