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首页> 美国卫生研究院文献>Biological Research >Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells
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Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells

机译：喀麦隆的花椒的果实和树皮提取物诱导人白血病HL-60细胞线粒体依赖性凋亡和Go / G1期阻滞

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BackgroundZanthoxylum heitzii is a spice used to prepare several dishes and to treat tumors, syphilis, malaria, cardiac palpitations, urogenital infections in the west region of Cameroon, but the antitumor mechanisms and chemical composition are not yet investigated.This study was aimed to determine the antiproliferative effects of four extracts from the fruits and barks of Zanthoxyllum heitzii (Rutaceae) on apoptosis in human promyelocytic cells, their mechanisms and the chemical composition. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the fifty percent inhibition (IC50) concentration of the cell lines after treatment. The effect on morphology was observed using a light or fluorescence microscopy. The rate of apoptosis and the cell cycle were measured using flow cytometry (FCM). The phytochemical analysis of the extract was carried with HPLC/MS methods.
机译：背景Zanthoxylum heitzii是一种香料，用于准备几道菜并治疗喀麦隆西部地区的肿瘤，梅毒，疟疾，心和泌尿生殖道感染，但尚未研究其抗肿瘤机制和化学成分。桔梗（Rantaceae）的果实和树皮的四种提取物对人早幼粒细胞凋亡的抑制作用，其机制和化学组成。使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）测定来确定处理后细胞系的百分之五十抑制（IC50）浓度。使用光或荧光显微镜观察对形态的影响。使用流式细胞仪（FCM）测量细胞凋亡率和细胞周期。提取物的植物化学分析采用HPLC / MS方法进行。

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