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Evolution of the genetic code: partial optimization of a random code for robustness to translation error in a rugged fitness landscape

机译:遗传密码的进化:在崎fitness不平的健身环境中对随机密码进行部分优化以增强对翻译错误的鲁棒性

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摘要

BackgroundThe standard genetic code table has a distinctly non-random structure, with similar amino acids often encoded by codons series that differ by a single nucleotide substitution, typically, in the third or the first position of the codon. It has been repeatedly argued that this structure of the code results from selective optimization for robustness to translation errors such that translational misreading has the minimal adverse effect. Indeed, it has been shown in several studies that the standard code is more robust than a substantial majority of random codes. However, it remains unclear how much evolution the standard code underwent, what is the level of optimization, and what is the likely starting point.
机译:背景技术标准遗传密码表具有明显的非随机结构,通常由密码子系列编码的相似氨基酸之间的差异在于单个核苷酸取代,通常在密码子的第三位或第一位。反复争论过,代码的这种结构是由于对鲁棒性对翻译错误的鲁棒性进行选择性优化而产生的,从而使翻译误读具有最小的不利影响。确实,在一些研究中已经表明,标准代码比绝大多数随机代码更健壮。但是,目前尚不清楚标准代码进行了多少演变,优化的级别是什么以及可能的起点是什么。

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