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Synthesis Characterization and Biological Activity of N′-(Z)-(3-Methyl-5-oxo-1-phenyl-15-dihydro-4H-pyrazol-4-ylidene)(phenyl)methylbenzohydrazide and Its Co(II) Ni(II) and Cu(II) Complexes

机译：N的合成表征与生物活性′-（Z）-（3-甲基-5-氧代-1-苯基-15-二氢-4H-吡唑-4-亚烷基）（苯基）甲基苯并肼及其钴（II）镍（II））和Cu（II）配合物

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Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gave N ^′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL¹), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL¹ with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for their in vitro cytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC50 value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.

机译：1-苯-3-甲基-4-苯甲酰基-吡唑-5-酮与苯甲酰肼在回流的乙醇中反应，得到N ^{'-[（Z）-（3-甲基-5-氧代- 1-苯基-1,5-二氢-4H-吡唑-4-亚烷基）（苯基）甲基]苯并肼（HL ^{1 ）的核磁共振波谱和单晶X射线结构表征研究。晶体的X射线衍射分析表明，存在一个以酮胺形式存在的非平面分子，分子间氢键形成了一个七元环系统。 HL ^{1 与Co（II），Ni（II）和Cu（II）卤化物的反应生成相应的配合物，并通过元素分析，摩尔电导，磁测量以及红外和红外光谱对其进行表征。电子光谱研究。筛选化合物对HL-60人早幼粒细胞白血病细胞的体外细胞毒活性以及对某些细菌和酵母菌的抗菌活性。结果表明，该化合物对HL-60细胞有效，IC50值≤5μm，而某些化合物对少数研究的革兰氏阳性细菌具有活性。}}}

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期刊名称 Bioinorganic Chemistry and Applications
作者
Jonnie N. Asegbeloyin; Oguejiofo T. Ujam; Emmanuel C. Okafor; Ilknur Babahan; Esin Poyrazoglu Coban; Ali Özmen; Halil Biyik;
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作者单位

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年(卷),期 2014(2014),-1
年度 2014
页码 718175
总页数 11
原文格式 PDF
正文语种
中图分类分子生物学;
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机译：N'-[（Z）-（3-甲基-5-氧代-1-苯基-1,5-二氢-4H-吡唑-4-亚烷基）（苯基）甲基]苯并肼的合成，表征和生物活性（II），Ni（II）和Cu（II）配合物
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Synthesis Characterization and Biological Activity of N′-(Z)-(3-Methyl-5-oxo-1-phenyl-15-dihydro-4H-pyrazol-4-ylidene)(phenyl)methylbenzohydrazide and Its Co(II) Ni(II) and Cu(II) Complexes

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