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Thermal and Physico-Mechanical Characterizations of Thromboresistant Polyurethane Films

机译：抗血栓聚氨酯薄膜的热和物理力学表征

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摘要

Hemocompatibility remains a challenge for injectable and/or implantable medical devices, and thromboresistant coatings appear to be one of the most attractive methods to down-regulate the unwanted enzymatic reactions that promote the formation of blood clots. Among all polymeric materials, polyurethanes (PUs) are a class of biomaterials with excellent biocompatibility and bioinertness that are suitable for the use of thromboresistant coatings. In this work, we investigated the thermal and physico-mechanical behaviors of ester-based and ether-based PU films for potential uses in thromboresistant coatings. Our results show that poly(ester urethane) and poly(ether urethane) films exhibited characteristic peaks corresponding to their molecular configurations. Thermal characterizations suggest a two-step decomposition process for the poly(ether urethane) films. Physico-mechanical characterizations show that the surfaces of the PU films were hydrophobic with minimal weight changes in physiological conditions over 14 days. All PU films exhibited high tensile strength and large elongation to failure, attributed to their semi-crystalline structure. Finally, the in vitro clotting assays confirmed their thromboresistance with approximately 1000-fold increase in contact time with human blood plasma as compared to the glass control. Our work correlates the structure-property relationships of PU films with their excellent thromboresistant ability.
机译：血液相容性仍然是可注射和/或可植入医疗设备的挑战，抗血栓涂层似乎是下调促进血凝块形成的有害酶促反应的最有吸引力的方法之一。在所有聚合材料中，聚氨酯（PU）是一类具有出色的生物相容性和生物惰性的生物材料，适合用于抗血栓涂层。在这项工作中，我们研究了酯基和醚基PU膜的热和物理力学行为，这些膜可用于抗血栓涂料。我们的结果表明，聚（酯氨基甲酸酯）和聚（醚氨基甲酸酯）薄膜表现出对应于其分子构型的特征峰。热表征表明聚（醚氨基甲酸酯）薄膜的两步分解过程。物理力学特性表明，PU膜的表面具有疏水性，在14天的生理条件下，其重量变化很小。由于其半结晶结构，所有PU膜均表现出高拉伸强度和较大的断裂伸长率。最终，体外凝结试验证实了它们的血栓形成抗性，与玻璃质对照相比，与人血浆的接触时间增加了约1000倍。我们的工作将PU膜的结构特性关系与其出色的抗血栓形成能力联系起来。

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