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首页> 美国卫生研究院文献>The Journal of Neuroscience >Cellular Traces of Behavioral Classical Conditioning Can Be Recorded at Several Specific Sites in a Simple Nervous System
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Cellular Traces of Behavioral Classical Conditioning Can Be Recorded at Several Specific Sites in a Simple Nervous System

机译：行为经典条件的细胞痕迹可以记录在一个简单的神经系统中的几个特定位置

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We used a behavioral learning paradigm followed by electrophysiological analysis to find sites in theLymnaea feeding network in which electrical changes could be recorded after appetitive conditioning. Specifically, we analyzed conditioning-induced changes in cellular responses in the mechanosensory conditioned stimulus (CS) pathway, in the central pattern generator (CPG) network, and in feeding motoneurons. During training, experimental animals received 15 pairings of lip touch (the CS) with sucrose (the unconditioned stimulus, US). Control animals received 15 random CS and US presentations. Electrophysiological tests on semi-intact preparations made from conditioned animals demonstrated a network correlate of the overall feeding conditioned response, a touch-evoked CPG-driven fictive feeding rhythm. At the motoneuronal level, we found significant conditioning-induced increases in the amplitude of an early touch-evoked EPSP and spike activity, recorded from the B3 feeding motoneuron. Increases in EPSP amplitude and motoneuronal spike activity could occur independently of conditioned fictive feeding. These changes in response recorded at the level of CPG interneurons, and motoneurons were preceded by changes recorded in the CS pathway. This was demonstrated by recording a conditioning-induced increase in the number of touch-evoked spikes in the cerebrobuccal connective, which forms part of the CS pathway. The finding that electrophysiological changes after conditioning can be recorded at multiple sites in this simple system provided an important intermediate level of analysis between whole animal behavior and cellular studies on the synaptic sites of plasticity.
机译：我们使用了行为学习范式，然后进行电生理分析，以发现林蛙饲喂网络中的一些位置，在这些条件下，经过食性调节后可以记录电变化。具体来说，我们分析了机械感应条件刺激（CS）路径，中央模式发生器（CPG）网络和运动神经元的进食中条件诱导的细胞反应变化。在训练过程中，实验动物接受了15对嘴唇接触（CS）与蔗糖（美国无条件刺激）的配对。对照动物接受了15次随机CS和US展示。对由条件动物制成的半完整制剂的电生理学测试表明，总体喂养条件反应（触摸诱发的CPG驱动的虚拟喂养节奏）与网络相关。在动脑神经元水平上，我们发现从B3喂入的运动神经元记录到的条件诱发的早期触摸诱发的EPSP振幅和突波活性显着增加。 EPSP振幅和单动性神经突增活动的增加可能独立于有条件的虚拟喂养而发生。在CPG中间神经元和运动神经元水平记录的这些反应变化之前，在CS途径中记录了变化。这通过记录条件诱发的大脑颊结缔组织中触摸诱发的尖峰数目的增加来证明，这是CS路径的一部分。在这个简单的系统中，可以在调节后的多个部位记录调节后的电生理变化的发现，为整个动物行为与可塑性突触部位的细胞研究之间提供了重要的中间分析水平。

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