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Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase.

机译：有证据表明胰岛素通过体内丙酮酸脱氢酶和乙酰辅酶A羧化酶的平行活化机制可以增加体内冷适应大鼠的肩cap棕色脂肪组织中脂肪酸的合成。

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Plasma insulin concentrations in cold-adapted rats were altered acutely by administration of glucose or anti-insulin serum. Rates of fatty acid synthesis in interscapular brown adipose tissue were determined from the incorporation of 3H from 3H2O into tissue lipid. Rates of synthesis were greatly elevated after glucose administration and markedly decreased after injection with anti-insulin serum. Parallel changes in the initial activities of both acetyl-CoA carboxylase and pyruvate dehydrogenase were observed under these conditions, but no changes in total activities were evident. The results suggest that this tissue is an important site of fatty acid synthesis in the cold-adapted rat and that this feature of the tissue is sensitive to changes in plasma insulin concentrations.

机译：服用葡萄糖或抗胰岛素血清后，冷适应大鼠的血浆胰岛素浓度急剧变化。通过将3H2O中的3H掺入组织脂质中，确定肩cap间棕色脂肪组织中脂肪酸的合成速率。葡萄糖给药后，合成速率大大提高，注射抗胰岛素血清后，合成速率显着降低。在这些条件下，可以观察到乙酰辅酶A羧化酶和丙酮酸脱氢酶的初始活性平行变化，但总活性没有明显变化。结果表明该组织是冷适应大鼠中脂肪酸合成的重要部位，并且该组织的特征对血浆胰岛素浓度的变化敏感。

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期刊名称 Biochemical Journal
作者
J G McCormack; R M Denton;
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作者单位

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年(卷),期 1977(166),3
年度 1977
页码 627–630
总页数 5
原文格式 PDF
正文语种
中图分类分子生物学;
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1. Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase [J] . J G McCormack, R M Denton The biochemical journal . 1977,第3期

机译：胰岛素通过涉及丙酮酸脱氢酶和乙酰辅酶A羧化酶平行激活的机制在体内增强冷适应大鼠肩s棕色脂肪组织中脂肪酸合成的证据
2. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats [J] . D Stansbie, M Crettaz, R M Denton, The biochemical journal . 1976,第2期

机译：抗胰岛素血清对大鼠肝及附睾脂肪组织脂肪酸合成速率及乙酰辅酶A羧化酶和丙酮酸脱氢酶活性的急性影响
3. Evidence that noradrenaline increases pyruvate dehydrogenase activity and decreases acetyl-CoA carboxylase activity in rat interscapular brown adipose tissue in vivo [J] . J G McCormack, J M Gibbins, R M Denton The biochemical journal . 1985,第3期

机译：体内去甲肾上腺素增加丙酮酸脱氢酶活性并降低乙酰辅酶A羧化酶活性的证据
4. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. [O] . D Stansbie, R W Brownsey, M Crettaz, 1976

机译：抗胰岛素血清在体内对饲喂大鼠肝脏和附睾脂肪组织中脂肪酸合成速率以及乙酰辅酶A羧化酶和丙酮酸脱氢酶活性的急性影响。
5. Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase. [O] . McCormack, J G, Denton, R M 1977

机译：有证据表明，胰岛素通过体内丙酮酸脱氢酶和乙酰辅酶A羧化酶的平行活化机制，可以增加体内冷适应大鼠的肩cap棕色脂肪组织中脂肪酸的合成。

Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase.

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