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Fructose 26-bisphosphate and its phosphorothioate analogue. Comparison of their hydrolysis and action on glycolytic and gluconeogenic enzymes.

机译：果糖26-二磷酸及其硫代磷酸酯类似物。比较它们的水解作用和对糖酵解和糖异生酶的作用。

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摘要

Purified chicken liver 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase was phosphorylated either from fructose 2,6-bis[2-32P]phosphate or fructose 2-phosphoro[35S]thioate 6-phosphate. The turnover of the thiophosphorylated enzyme intermediate as well as the overall phosphatase reaction was four times faster than with authentic fructose 2,6-bisphosphate. Fructose 2-phosphorothioate 6-phosphate was 10-100-fold less potent than authentic fructose 2,6-bisphosphate in stimulating 6-phosphofructo-1-kinase and pyrophosphate:fructose 6-phosphate phosphotransferase, but about 10 times more potent in inhibiting fructose 1,6-bisphosphatase. The analogue was twice as effective as authentic fructose 2,6-bisphosphate in stimulating pyruvate kinase from trypanosomes.

机译：将纯化的鸡肝6-磷酸果糖-2-激酶/果糖2,6-双磷酸酶从果糖2,6-双[2-32P]磷酸或果糖2-磷酸[35S]硫代磷酸6-磷酸中磷酸化。硫代磷酸化酶中间体的转化率以及整个磷酸酶反应的速度比真正的果糖2,6-双磷酸酯要快四倍。在刺激6-磷酸果糖-1-激酶和焦磷酸：果糖6-磷酸磷酸转移酶方面，果糖2-磷酸硫代磷酸6-磷酸的效力比真正的果糖2,6-二磷酸低10-100倍，但抑制果糖的效力却高约10倍1,6-双磷酸酶。在刺激锥虫体中的丙酮酸激酶时，该类似物的功效是真正的果糖2,6-二磷酸的两倍。

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期刊名称 Biochemical Journal
作者
M H Rider; D A Kuntz; L Hue;
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年(卷),期 1988(253),2
年度 1988
页码 597–601
总页数 5
原文格式 PDF
正文语种
中图分类分子生物学;
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专利

1. Fructose 2,6-bisphosphate and its phosphorothioate analogue. Comparison of their hydrolysis and action on glycolytic and gluconeogenic enzymes [J] . D A Kuntz, L Hue, M H Rider The biochemical journal . 1988,第2期

机译：果糖2,6-二磷酸及其硫代磷酸酯类似物。它们的水解作用和对糖酵解和糖异生酶的作用比较
2. Fructose 2,6-bisphosphate and its phosphorothioate analogue. Comparison of their hydrolysis and action on glycolytic and gluconeogenic enzymes [J] . D A Kuntz, L Hue, M H Rider The biochemical journal . 1988,第2期

机译：果糖2,6-二磷酸及其硫代磷酸酯类似物。它们的水解作用和对糖酵解和糖异生酶的作用比较
3. Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. [J] . Wu C, Khan SA, Peng LJ, Advances in enzyme regulation . 2006,第0期

机译：2,6-二磷酸果糖在燃料代谢控制中的作用：其对糖酵解和糖异生酶的变构作用。
4. Comparison of Liquid/Liquid and Solid-Phase Extraction for the Quantitative Analysis of Phosphorothioate Oligonucleotides in Human Plasma Using LC/MS/MS [C] . Weiwei Yuan, Laixin Wang, Yue Zhao, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：用LC / MS / MS对人血浆中硫代磷酸锂寡核苷酸定量分析的液/液和固相提取的比较
5. Enzyme, cosolvent and substrate interactions in PLE hydrolysis reactions and evaluation of the stability of an unnatural glutathione analogue. [D] . Smith, Maureen Elizabeth. 2014

机译：PLE水解反应中的酶，助溶剂和底物相互作用以及非天然谷胱甘肽类似物的稳定性评估。
6. Banana Ripening: Implications of Changes in Glycolytic Intermediate Concentrations Glycolytic and Gluconeogenic Carbon Flux and Fructose 26-Bisphosphate Concentration [O] . Randolph M. Beaudry, Ray F. Severson, Clanton C. Black, 1989

机译：香蕉成熟：糖酵解中间浓度糖酵解和葡萄糖生成碳通量以及果糖26-二磷酸浓度变化的影响
7. Fructose 2,6-bisphosphate and its phosphorothioate analogue. Comparison of their hydrolysis and action on glycolytic and gluconeogenic enzymes. [O] . Rider, M H, Kuntz, D A, Hue, L 1988

机译：果糖2,6-二磷酸及其硫代磷酸酯类似物。比较它们的水解作用和对糖酵解和糖异生酶的作用。

Fructose 26-bisphosphate and its phosphorothioate analogue. Comparison of their hydrolysis and action on glycolytic and gluconeogenic enzymes.

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