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Identical regional mechanisms of intracellular free Ca2+ concentration increase during polarized agonist-evoked Ca2+ response in pancreatic acinar cells.

机译：胰腺腺泡细胞极化激动剂诱发的Ca2 +反应期间细胞内游离Ca2 +浓度增加的相同区域机制。

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摘要

The initial increase of intracellular free Ca2+ concentration ([Ca2+]i) following agonist stimulation is spatially restricted to one pole of the cell, from where a wave of [Ca2+]i spreads across the cytosol. In the present study we have investigated the dynamic properties of the agonist-activated Ca(2+)-release mechanisms in different regions of the acinar cell and show that, during maximal agonist stimulation, the rate of [Ca2+]i increase at the secretory pole is identical with that recorded at the basal pole. Furthermore, the relationship between [Ca2+]i and the apparent rate of [Ca2+]i increase is similar in both regions of the cell. The data show that whereas the sensitivity to the Ca(2+)-releasing agent is different in different regions of the cell, the process of [Ca2+]i increase, once triggered, will proceed in an identical fashion, irrespective of the area of the cell.

机译：激动剂刺激后细胞内游离Ca2 +浓度（[Ca2 +] i）的初始增加在空间上限制在细胞的一个极点，[Ca2 +] i波从那里扩散到整个细胞质中。在本研究中，我们研究了在腺泡细胞不同区域中激动剂激活的Ca（2+）释放机制的动力学特性，并显示在最大激动剂刺激过程中，分泌物中[Ca2 +] i的比率增加极点与基极记录的极点相同。此外，在细胞的两个区域中，[Ca 2+] i与[Ca 2+] i的表观速率增加之间的关系相似。数据显示，尽管在细胞的不同区域中对Ca（2+）释放剂的敏感性不同，但是[Ca2 +] i的增加过程一旦触发，将以相同的方式进行，而与细胞的面积无关。细胞。

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期刊名称 Biochemical Journal
作者
E C Toescu; D V Gallacher; O H Petersen;
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作者单位

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年(卷),期 1994(304),Pt 1
年度 1994
页码 313–316
总页数 4
原文格式 PDF
正文语种
中图分类分子生物学;
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1. Identical regional mechanisms of intracellular free Ca2+ concentration increase during polarized agonist-evoked Ca2+ response in pancreatic acinar cells [J] . D V Gallacher, E C Toescu, O H Petersen The biochemical journal . 1994,第1期

机译：胰腺腺泡细胞极化激动剂诱发的Ca2 +响应过程中细胞内游离Ca2 +浓度增加的相同区域机制
2. Thiol oxidation by 2,2′-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic β-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores [J] . Henrik KINDMARK, Md. Shahidul ISLAM, Olof LARSSON, The biochemical journal . 1997,第2期

机译：2,2'-二硫代二吡啶对硫醇的氧化作用会导致胰腺β细胞中胞质游离Ca2 +浓度的可逆增加。肌醇1,4,5-三磷酸敏感的Ca2 +存储的作用
3. Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool [J] . A Hallberg, H Kindmark, P Arkhammar, The biochemical journal . 1990,第1期

机译：细胞外ATP增加了克隆产生胰岛素的RINm5F细胞的细胞质游离Ca2 +浓度。涉及与肌醇1,4,5-三磷酸酯敏感的Ca2 +库的释放和再填充直接相互作用的机制
4. Real-time monitoring of Ca2+ concentration in pancreatic beta cells by a microfluidic device integrated with Total Internal Reflection (TIR)-based chip [C] . Kitazawa Y., Yokokawa R., Terao K., International Conference on Micro Electro Mechanical Systems . 2011

机译：通过与全内反射（TIR）为基础的微流体装置实时监测胰β细胞中的Ca 2 + / sup>浓度
5. In vivo loss of estrogen increases Ca2+ influx via voltage-gated calcium channels in mesenteric arterial smooth muscle cells. [D] . Fernando, Charmain Angela. 2013

机译：体内雌激素的损失通过电压门控的钙离子通道增加肠系膜动脉平滑肌细胞中的Ca2 +流入。
6. Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 145-trisphosphate-sensitive Ca2+ pool. [O] . P Arkhammar, A Hallberg, H Kindmark, 1990

机译：细胞外ATP增加了克隆产生胰岛素的RINm5F细胞的细胞质游离Ca2 +浓度。涉及与肌醇145-三磷酸酯敏感的Ca2 +库的释放和再填充直接相互作用的机制。
7. Identical regional mechanisms of intracellular free Ca2+ concentration increase during polarized agonist-evoked Ca2+ response in pancreatic acinar cells. [O] . Toescu, E C, Gallacher, D V, Petersen, O H 1994

机译：胰腺腺泡细胞极化激动剂诱发的Ca2 +反应期间，细胞内游离Ca2 +浓度增加的相同区域机制。

Identical regional mechanisms of intracellular free Ca2+ concentration increase during polarized agonist-evoked Ca2+ response in pancreatic acinar cells.

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