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首页> 美国卫生研究院文献>The Journal of Neuroscience >Neuronal Size in the Spinal Nucleus of the Bulbocavernosus: Direct Modulation by Androgen in Rats with Mosaic Androgen Insensitivity
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Neuronal Size in the Spinal Nucleus of the Bulbocavernosus: Direct Modulation by Androgen in Rats with Mosaic Androgen Insensitivity

机译：球海绵体脊髓核中的神经元大小：雄性激素对镶嵌性雄激素不敏感性大鼠的直接调节作用

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The motoneurons of the spinal nucleus of the bulbocavernosus (SNB) and its target muscles, the bulbocavernosus and levator ani, form a sexually dimorphic circuit that is developmentally dependent on androgen exposure and exhibits numerous structural and functional changes in response to androgen exposure in adulthood. Castration of male adult rats causes shrinkage of SNB somata, and testosterone replacement reverses this effect, but the site at which androgen is acting to cause this change is undetermined. We exploited the X-chromosome residency of the androgen receptor (AR) gene to generate androgenized female rats that were heterozygous for the testicular feminization mutant (tfm) AR mutation and that, as a consequence of ontogenetic random X-inactivation, expressed a blend of androgen-sensitive wild-type cells and tfm-affected androgen-insensitive cells in the SNB. Chronic testosterone treatment of adult mosaics increased soma sizes only in androgen-competent wild-type SNB cells. The size of tfm-affected SNB somata in the same animals did not differ from the size of either the wild-type or tfm-affected SNB neurons in control mosaics that did not receive androgen treatment in adulthood. Because the muscle targets of the SNB are known to be uniformly androgen-sensitive in tfm mosaics, this mosaic analysis provides unambiguous evidence that androgenic effects on motoneuron soma size are mediated locally in the SNB. It is possible that the neuronal AR plays a permissive role in coordinating the actions of androgen.
机译：球囊海绵状肌（SNB）的脊髓神经核及其靶肌肉，球囊海绵状肌和提肛动物形成了性二态性回路，该性状在发育上取决于雄激素暴露，并且在成年后响应于雄激素暴露表现出许多结构和功能变化。雄性成年大鼠去势导致SNB躯体萎缩，而睾丸激素替代可逆转这种作用，但尚不确定雄激素起作用的部位。我们利用雄激素受体（AR）基因的X染色体驻留能力来生成雄激素雌性大鼠，该雌性大鼠的睾丸女性化突变体（tfm）AR突变是杂合的，并且由于个体遗传随机X失活而表达了一种SNB中的雄激素敏感野生型细胞和受tfm影响的雄激素不敏感细胞。慢性睾丸激素治疗成年马赛克仅在雄激素适应性野生型SNB细胞中增加了体细胞大小。同一动物中受tfm影响的SNB躯体的大小与成年未接受雄激素治疗的对照马赛克中野生型或受tfm影响的SNB神经元的大小没有差异。因为已知SNB的肌肉目标在tfm镶嵌中对雄激素均匀敏感，所以该镶嵌分析提供了明确的证据，证明对SNB的运动神经元躯体大小有雄激素作用。神经元AR可能在协调雄激素的作用中起了宽松的作用。

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