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Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

机译:粉末冶金Ti-Mg金属-金属复合材料有助于骨科应用中的骨传导和骨整合

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摘要

In this work, Ti—Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti—Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti—Mg MMCs implants were embedded into the femur condyles. Results showed that Ti—Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti—Mg implants than around Ti implants, indicating that more active new-bone formed around Ti—Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti—Mg implants than that around Ti implants.
机译:在这项工作中,通过火花等离子体烧结(SPS)成功地制造了Ti-Mg金属-金属复合材料(MMC)。在体外,研究了响应于Ti-Mg金属-金属复合材料(MMC)的SaOS-2细胞的增殖和分化。在体内,采用具有股骨con缺损的大鼠模型,并将Ti-Mg MMCs植入物植入股骨con中。结果表明,Ti-Mg MMC比纯Ti对SaOS-2 Sa细胞的细胞相容性增强。显微计算机断层扫描(Micro-CT)结果显示,Ti-Mg植入物周围的骨小梁体积比Ti植入物周围的骨小梁量明显更多,这表明Ti-Mg MMC植入物周围形成了更活跃的新骨。苏木精-曙红(H&E)染色分析显示,Ti-Mg植入物周围的骨整合明显大于Ti植入物周围的骨整合。

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