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首页> 美国卫生研究院文献>Behavioural Neurology >The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants
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The Effect of Task-Irrelevant Fearful-Face Distractor on Working Memory Processing in Mild Cognitive Impairment versus Healthy Controls: An Exploratory fMRI Study in Female Participants

机译：轻度认知障碍与健康对照组相比任务增强剂恐惧面孔分散器对工作记忆处理的作用：女性参与者的功能性MRI研究

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In mild cognitive impairment (MCI), a risk state for Alzheimer's disease, patients have objective cognitive deficits with relatively preserved functioning. fMRI studies have identified anomalies during working memory (WM) processing in individuals with MCI. The effect of task-irrelevant emotional face distractor on WM processing in MCI remains unclear. We aim to explore the impact of fearful-face task-irrelevant distractor on WM processing in MCI using fMRI. Hypothesis. Compared to healthy controls (HC), MCI patients will show significantly higher BOLD signal in a priori identified regions of interest (ROIs) during a WM task with a task-irrelevant emotional face distractor. Methods. 9 right-handed female participants with MCI and 12 matched HC performed a WM task with standardized task-irrelevant fearful versus neutral face distractors randomized and counterbalanced across WM trials. MRI images were acquired during the WM task and BOLD signal was analyzed using statistical parametric mapping (SPM) to identify signal patterns during the task response phase. Results. Task-irrelevant fearful-face distractor resulted in higher activation in the amygdala, anterior cingulate, and frontal areas, in MCI participants compared to HC. Conclusions. This exploratory study suggests altered WM processing as a result of fearful-face distractor in MCI.
机译：在轻度认知障碍（MCI）（阿尔茨海默氏病的风险状态）中，患者存在客观的认知缺陷，功能相对保留。功能磁共振成像研究已发现MCI患者在工作记忆（WM）处理过程中出现异常。与任务无关的情绪面部干扰对MCI中WM处理的影响尚不清楚。我们的目的是使用功能磁共振成像研究恐惧面孔无关的干扰因素对MCI中WM处理的影响。假设。与健康对照（HC）相比，MCI患者在与任务无关的情绪面部干扰物的WM任务期间，在先验确定的感兴趣区域（ROI）中将显示明显更高的BOLD信号。方法。 9名MCI右撇子女性参与者和12名相匹配的HC参加了一项WM任务，并在WM试验中随机分配和平衡了标准化的与任务无关的恐惧相对于自然的面部干扰物。在WM任务期间获取MRI图像，并使用统计参数映射（SPM）分析BOLD信号以识别任务响应阶段的信号模式。结果。与任务无关的恐惧面部干扰物比HC导致MCI参与者的杏仁核，前扣带回和额叶区域的激活更高。结论。这项探索性研究表明，由于MCI中令人恐惧的面部干扰因素，导致WM处理过程发生了变化。

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