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首页> 美国卫生研究院文献>The Journal of Neuroscience >Lower-Frequency Event-Related Desynchronization: A Signature of Late Mismatch Responses to Sounds Which Is Reduced or Absent in Children with Specific Language Impairment
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Lower-Frequency Event-Related Desynchronization: A Signature of Late Mismatch Responses to Sounds Which Is Reduced or Absent in Children with Specific Language Impairment

机译：低频事件相关的失步：对声音的后期失配反应的一种特征这种声音在患有特定语言障碍的儿童中减少或不存在

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Poor discrimination of nonlinguistic sounds has been implicated in language-learning problems in children, but research evidence has been inconsistent. This study included 32 participants with specific language impairment (SLI) and 32 typically developing controls aged 7–16 years. Frequency discrimination thresholds were estimated in a task where participants had to distinguish a higher-frequency tone from a 1000 Hz tone. Neurophysiological responses were assessed in an oddball paradigm. Stimuli were either 1030 or 1200 Hz pure tones (deviants) presented in a series of standard 1000 Hz tones, or syllables (deviant [da] or [bi] in a series of standard /ba/). On the behavioral task, children (7- to 11-year-olds) had high thresholds, regardless of language status, but teenagers (12–16 years) with SLI had higher thresholds than their controls. Conventional analysis of electrophysiological responses showed no difference between groups for the mismatch negativity (MMN), but the late discriminative negativity (LDN) was reduced in amplitude for smaller deviants in participants with SLI. Time–frequency analysis revealed that, whereas the MMN reflected enhanced intertrial coherence in the theta frequency band, the LDN corresponded to a period of event-related desynchronization extending across a wide low-frequency band including delta, theta, and alpha. This manifested as a drop in power in those frequencies, which was marked in the controls but reduced or absent in children with SLI across all stimulus types. This provides compelling evidence for a low-level auditory perceptual impairment in SLI that affects a processing stage after initial detection of a sound change.
机译：非语言声音的辨别力差与儿童的语言学习问题有关，但研究证据并不一致。这项研究包括32位具有特定语言障碍（SLI）的参与者和32位通常发展为7-16岁的对照组。在一项任务中，参与者必须将高频音调与1000 Hz音调区分开来，估计频率歧视阈值。神经生理反应是在一个奇怪的范式中评估的。刺激是一系列标准1000 Hz音调中出现的1030或1200 Hz纯音（偏差），或者是音节（一系列标准/ ba /中出现偏差d或[bi]）。在行为任务上，不论语言水平如何，儿童（7至11岁）的阈值都较高，但是患有SLI的青少年（12-16岁）的阈值要高于对照组。传统的电生理反应分析显示，两组之间的错配负性（MMN）没有差异，但是对于SLI参与者中较小的偏差，后期判别性负性（LDN）的幅度减小了。时频分析表明，尽管MMN反映了theta频带内增强的内部相干性，但LDN对应于事件相关的失步时间段，该失谐时间跨过一个广泛的低频频带，包括delta，theta和alpha。这表现为那些频率的功率下降，这在对照组中是明显的，但在所有刺激类型中，SLI儿童均降低或不存在。这提供了令人信服的证据，表明SLI中的低水平听觉感知障碍会在最初检测到声音变化后影响处理阶段。

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