• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The Journal of Neuroscience >Mirrored Bilateral Slow-Wave Cortical Activity within Local Circuits Revealed by Fast Bihemispheric Voltage-Sensitive Dye Imaging in Anesthetized and Awake Mice
【2h】

Mirrored Bilateral Slow-Wave Cortical Activity within Local Circuits Revealed by Fast Bihemispheric Voltage-Sensitive Dye Imaging in Anesthetized and Awake Mice

机译：麻醉和清醒小鼠的快速双半球电压敏感染料成像揭示了局部电路内的镜像双边慢波皮层活动。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Spontaneous slow-wave oscillations of neuronal membrane potential occur about once every second in the rodent cortex and may serve to shape the efficacy of evoked neuronal responses and consolidate memory during sleep. However, whether these oscillations reflect the entrainment of all cortical regions via propagating waves or whether they exhibit regional and temporal heterogeneity that reflects processing in local cortical circuits is unknown. Using voltage-sensitive dye (VSD) imaging within an adult C57BL/6J mouse cross-midline large craniotomy preparation, we recorded this depolarizing activity across most of both cortical hemispheres simultaneously in both anesthetized and quiet awake animals. Spontaneous oscillations in the VSD signal were highly synchronized between hemispheres, and acallosal I/LnJ mice indicated that synchrony depended on the corpus callosum. In both anesthetized and awake mice (recovered from anesthesia), the oscillations were not necessarily global changes in activity state but were made up of complex local patterns characterized by multiple discrete peaks that were unevenly distributed across cortex. Although the local patterns of depolarizing activity were complex and changed over tens of milliseconds, they were faithfully mirrored in both hemispheres in mice with an intact corpus callosum, to perhaps ensure parallel modification of related circuits in both hemispheres. We conclude that within global rhythms of spontaneous activity are complex events that reflect orchestrated processing within local cortical circuits.
机译：在啮齿动物皮层中，神经元膜电位的自发慢波振荡大约每秒发生一次，可能有助于塑造诱发的神经元反应的功效并巩固睡眠期间的记忆。然而，这些振荡是否通过传播波反映了所有皮质区域的夹带，或者它们是否表现出反映局部皮质回路处理的区域和时间异质性。使用成年C57BL / 6J小鼠跨中线大型颅骨切开术制剂中的电压敏感染料（VSD）成像，我们在麻醉和安静的清醒动物中同时记录了跨大多数两个皮层半球的去极化活性。 VSD信号中的自发振荡在半球之间高度同步，并且a骨I / LnJ小鼠表明同步性取决于call体。在麻醉和清醒的小鼠（从麻醉中恢复）中，振荡不一定是活动状态的整体变化，而是由复杂的局部模式组成，其特征是多个离散峰在皮质上分布不均。尽管去极化活性的局部模式很复杂，并且在几十毫秒内发生了变化，但它们在具有完整corp体的小鼠的两个半球中都得到了真实的反映，以确保两个半球中相关电路的平行修饰。我们得出结论，在全球范围内的自发活动节奏中，复杂的事件反映了局部皮层回路内精心策划的过程。

著录项

相似文献

  • 外文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号