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首页> 美国卫生研究院文献>The Journal of Neuroscience >Memory-Guided Learning: CA1 and CA3 Neuronal Ensembles Differentially Encode the Commonalities and Differences between Situations
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Memory-Guided Learning: CA1 and CA3 Neuronal Ensembles Differentially Encode the Commonalities and Differences between Situations

机译：记忆引导的学习：CA1和CA3神经元集成差异编码情况之间的共性和差异

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Memory influences learning, but how neural signals support such transfer are unknown. To investigate these mechanisms, we trained rats to perform a standard spatial memory task in a plus maze and tested how training affected learning and neural coding in two new task variants. A switch task exchanged the start and goal locations in the same environment, whereas, an altered environment task contained unfamiliar local and distal cues. Learning was facilitated in both variants compared with the acquisition of the standard task. In the switch task, performance was largely maintained, and was accompanied by immediate and stable place-field remapping. Place-field maps in CA1 were anticorrelated in the standard and switch sessions, and the anticorrelation covaried with switch performance. Simultaneously, CA3 maps were uncorrelated overall in the standard and switch, though many CA3 cells had fields in shifted locations in the same maze arms. In the altered environment, performance was initially impaired, and place fields changed dynamically. CA1 fields were initially unstable, and their stabilization correlated with improving performance. Most CA3 cells, however, stopped firing on the maze in the altered environment, even as the same cells maintained prominent fields in standard sessions recorded before and after. CA1 and CA3 place fields thus revealed different coding dynamics that correlated with both learning and memory performance. Together, CA1 and CA3 ensembles represented the similarities and differences between new and familiar situations through concurrent rate and place remapping.
机译：记忆会影响学习，但是神经信号如何支持这种转移尚不清楚。为了研究这些机制，我们训练了老鼠在迷宫中执行标准的空间记忆任务，并测试了训练如何影响两种新任务变体中的学习和神经编码。切换任务交换了同一环境中的开始和目标位置，而更改后的环境任务包含了不熟悉的局部和远端提示。与标准任务的获得相比，两种变体都促进了学习。在切换任务中，在很大程度上保持了性能，并伴随着立即而稳定的位置场重新映射。 CA1中的位置字段图在标准会话和交换会话中是反相关的，并且反相关与交换性能相关。同时，尽管许多CA3单元在同一迷宫臂中的移动位置具有场，但CA3映射在标准和转换中总体上是不相关的。在变化的环境中，性能最初受到损害，并且放置字段动态更改。 CA1场最初是不稳定的，它们的稳定与性能的提高相关。然而，大多数CA3细胞在改变后的环境中停止在迷宫中射击，即使相同的细胞在前后记录的标准会话中仍保持着突出的视野。因此，CA1和CA3放置字段显示出与学习和记忆性能相关的不同编码动态。 CA1和CA3集合通过并发速率和位置重映射共同表示新情况和熟悉情况之间的异同。

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