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首页> 美国卫生研究院文献>Proceedings of the Royal Society B: Biological Sciences >Pedigree-based inbreeding coefficient explains more variation in fitness than heterozygosity at 160 microsatellites in a wild bird population
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Pedigree-based inbreeding coefficient explains more variation in fitness than heterozygosity at 160 microsatellites in a wild bird population

机译：基于谱系的近交系数说明野生鸟类种群中160个微卫星的适应性比杂合性更多

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摘要

Although the pedigree-based inbreeding coefficient F predicts the expected proportion of an individual's genome that is identical-by-descent (IBD), heterozygosity at genetic markers captures Mendelian sampling variation and thereby provides an estimate of realized IBD. Realized IBD should hence explain more variation in fitness than their pedigree-based expectations, but how many markers are required to achieve this in practice remains poorly understood. We use extensive pedigree and life-history data from an island population of song sparrows (Melospiza melodia) to show that the number of genetic markers and pedigree depth affected the explanatory power of heterozygosity and F, respectively, but that heterozygosity measured at 160 microsatellites did not explain more variation in fitness than F. This is in contrast with other studies that found heterozygosity based on far fewer markers to explain more variation in fitness than F. Thus, the relative performance of marker- and pedigree-based estimates of IBD depends on the quality of the pedigree, the number, variability and location of the markers employed, and the species-specific recombination landscape, and expectations based on detailed and deep pedigrees remain valuable until we can routinely afford genotyping hundreds of phenotyped wild individuals of genetic non-model species for thousands of genetic markers.
机译：尽管基于谱系的近交系数F预测了个体基因组的预期比例，即后代相同（IBD），但遗传标记处的杂合性捕获了孟德尔采样变异，从而提供了已实现IBD的估计值。因此，已实现的IBD应该比基于谱系的期望解释更多的适应性变化，但是在实践中需要多少标记来实现这一点仍然知之甚少。我们使用来自岛麻雀岛（Melospiza melodia）的大量谱系和生活史数据显示遗传标记的数量和谱系深度分别影响杂合性和F的解释力，但是在160个微卫星上测得的杂合性确实不能解释比F适应性更大的变异。这与其他研究相反，其他研究发现杂合性基于更少的标记来解释比F适应性更大的变异。因此，基于标记和系谱的IBD估计的相对表现取决于谱系的质量，所用标记的数量，变异性和位置以及物种特异性的重组格局以及对详细而深厚的谱系的期望仍然很有价值，直到我们能够常规地对数百个非遗传性表型野生个体进行基因分型为止数以千计的遗传标记的模型物种。

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