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首页> 美国卫生研究院文献>The Journal of Neuroscience >Retrospectively and Prospectively Modulated Hippocampal Place Responses Are Differentially Distributed along a Common Path in a Continuous T-Maze
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Retrospectively and Prospectively Modulated Hippocampal Place Responses Are Differentially Distributed along a Common Path in a Continuous T-Maze

机译：追溯和前瞻性调制海马的地方反应沿着连续的T迷宫中的共同路径差异地分布。

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Hippocampal place responses can be prospectively or retrospectively modulated by the animal's future or prior trajectory. Two main hypotheses explain this. The “multiple-map hypothesis” switches between different maps for different trajectories (rate remapping). In contrast, in the “buffer hypothesis,” the hippocampus encodes an ongoing representation that includes the recent past and/or the impending future choice. This study examines the distribution of prospective and retrospective responses distributed along a common path in a continuous T-maze (providing all four combinations of provenance and destination) during a visual discrimination task. The multiple-map hypothesis predicts either uniform distributions or concerted shifts about a task-decision relevant point, whereas the buffer hypothesis predicts a time-limited overexpression around choice points (with retrospective responses after the central arm entry point and prospective responses nearer its exit). Here bilateral recordings in the dorsal CA1 region of the rat hippocampus show that retrospective responses were twice as prevalent as prospective responses. Furthermore, retrospective and prospective modulations have distinct spatial distributions, with retrospective primarily in the first two-thirds of the central arm and prospective restricted to the last third. To test for possible trial-by-trial remapping in relation to the two-thirds transition point, data from the first and second halves of the sessions were compared. Backward drift of path-modulated activity was significant only for retrospective, but not prospective, fields. Thus, these data are more consistent with the buffer hypothesis. Retrospective and prospective modulation would then participate in a single hippocampal representation of spatial and behavioral context.
机译：海马的地方反应可以通过动物的未来或先前的轨迹进行前瞻性或回顾性调节。有两个主要的假设可以解释这一点。 “多重地图假设”在不同地图的不同轨迹之间切换（速率重映射）。相反，在“缓冲假说”中，海马编码正在进行的表示，包括最近的过去和/或即将到来的未来选择。这项研究检查了在视觉辨别任务期间，在连续的T迷宫（提供来源和目的地的所有四种组合）中，沿着同一路径分布的前瞻性和回顾性响应的分布。多重图假设可预测任务决策相关点周围的均匀分布或一致偏移，而缓冲区假设可预测选择点周围的限时过表达（中心臂进入点后有追溯反应，出口附近有预期反应） 。在此，大鼠海马背CA1区的双侧记录显示，回顾性反应的发生率是预期反应的两倍。此外，回顾性和前瞻性调制具有明显的空间分布，回顾性主要在中心臂的前三分之二处进行，而前瞻性则限于后三分之一。为了测试相对于三分之二转换点的可能的逐次尝试重新映射，比较了会话的前半部分和后半部分的数据。路径调节活动的向后漂移仅对回顾性领域有意义，而对前瞻性领域则不重要。因此，这些数据与缓冲假说更一致。然后，回顾性和前瞻性调节将参与空间和行为情境的单个海马代表。

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