首页> 美国卫生研究院文献>The Journal of Neuroscience >Influences of Long-Term Memory-Guided Attention and Stimulus-Guided Attention on Visuospatial Representations within Human Intraparietal Sulcus
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Influences of Long-Term Memory-Guided Attention and Stimulus-Guided Attention on Visuospatial Representations within Human Intraparietal Sulcus

机译:长期记忆引导注意和刺激引导注意对人腹膜沟内视觉空间表征的影响

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摘要

Human parietal cortex plays a central role in encoding visuospatial information and multiple visual maps exist within the intraparietal sulcus (IPS), with each hemisphere symmetrically representing contralateral visual space. Two forms of hemispheric asymmetries have been identified in parietal cortex ventrolateral to visuotopic IPS. Key attentional processes are localized to right lateral parietal cortex in the temporoparietal junction and long-term memory (LTM) retrieval processes are localized to the left lateral parietal cortex in the angular gyrus. Here, using fMRI, we investigate how spatial representations of visuotopic IPS are influenced by stimulus-guided visuospatial attention and by LTM-guided visuospatial attention. We replicate prior findings that a hemispheric asymmetry emerges under stimulus-guided attention: in the right hemisphere (RH), visual maps IPS0, IPS1, and IPS2 code attentional targets across the visual field; in the left hemisphere (LH), IPS0-2 codes primarily contralateral targets. We report the novel finding that, under LTM-guided attention, both RH and LH IPS0-2 exhibit bilateral responses and hemispheric symmetry re-emerges. Therefore, we demonstrate that both hemispheres of IPS0-2 are independently capable of dynamically changing spatial coding properties as attentional task demands change. These findings have important implications for understanding visuospatial and memory-retrieval deficits in patients with parietal lobe damage.>SIGNIFICANCE STATEMENT The human parietal lobe contains multiple maps of the external world that spatially guide perception, action, and cognition. Maps in each cerebral hemisphere code information from the opposite side of space, not from the same side, and the two hemispheres are symmetric. Paradoxically, damage to specific parietal regions that lack spatial maps can cause patients to ignore half of space (hemispatial neglect syndrome), but only for right (not left) hemisphere damage. Conversely, the left parietal cortex has been linked to retrieval of vivid memories regardless of space. Here, we investigate possible underlying mechanisms in healthy individuals. We demonstrate two forms of dynamic changes in parietal spatial representations: an asymmetric one for stimulus-guided attention and a symmetric one for long-term memory-guided attention.
机译:人顶叶皮层在编码视觉空间信息中起着核心作用,并且顶内沟(IPS)中存在多个视觉图,每个半球对称地代表对侧视觉空间。在顶叶皮层腹侧相对于视觉性IPS已确定了两种形式的半球不对称。关键注意过程位于颞顶交界处的右侧顶叶皮层,而长期记忆(LTM)检索过程位于角回中的左侧顶叶皮层。在这里,使用功能磁共振成像,我们调查视觉引导的视觉空间注意和LTM引导的视觉空间注意如何影响视觉IPS的空间表示。我们复制了先前的发现,即在刺激引导的注意下出现了半球不对称:在右半球(RH)中,视觉图IPS0,IPS1和IPS2编码了整个视野中的注意目标;在左半球(LH)中,IPS0-2主要编码对侧目标。我们报告了新颖的发现,在LTM的指导下,RH和LH IPS0-2均显示出双边响应,并且半球对称重新出现。因此,我们证明IPS0-2的两个半球都能够独立地随着关注任务需求的变化而动态地改变空间编码属性。这些发现对于理解顶叶损伤患者的视觉空间和记忆恢复功能缺陷具有重要意义。>重要意义声明人的顶叶包含外部空间的多张地图,这些地图在空间上指导着感知,行动和认知。每个大脑半球中的映射从空间的另一侧而不是从同一侧编码信息,并且两个半球是对称的。矛盾的是,对缺少空间图的特定壁区域的损害可能导致患者忽略一半的空间(半边肌疏忽综合征),但仅对右半球(而不是左半球)造成损害。相反,无论空间大小如何,左顶叶皮层都与生动的记忆恢复有关。在这里,我们调查健康个体中可能的潜在机制。我们演示了两种形式的壁顶空间表示形式的动态变化:一种非对称形式用于刺激引导注意,另一种对称形式用于长期记忆引导注意。

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