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首页> 美国卫生研究院文献>The Journal of Neuroscience >A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles
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A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles

机译：果蝇翅K毛对机械刺激的防御性踢腿行为

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摘要

Mechanosensation, one of the fastest sensory modalities, mediates diverse behaviors including those pertinent for survival. It is important to understand how mechanical stimuli trigger defensive behaviors. Here, we report that Drosophila melanogaster adult flies exhibit a kicking response against invading parasitic mites over their wing margin with ultrafast speed and high spatial precision. Mechanical stimuli that mimic the mites' movement evoke a similar kicking behavior. Further, we identified a TRPV channel, Nanchung, and a specific Nanchung-expressing neuron under each recurved bristle that forms an array along the wing margin as being essential sensory components for this behavior. Our electrophysiological recordings demonstrated that the mechanosensitivity of recurved bristles requires Nanchung and Nanchung-expressing neurons. Together, our results reveal a novel neural mechanism for innate defensive behavior through mechanosensation.>SIGNIFICANCE STATEMENT We discovered a previously unknown function for recurved bristles on the Drosophila melanogaster wing. We found that when a mite (a parasitic pest for Drosophila) touches the wing margin, the fly initiates a swift and accurate kick to remove the mite. The fly head is dispensable for this behavior. Furthermore, we found that a TRPV channel, Nanchung, and a specific Nanchung-expressing neuron under each recurved bristle are essential for its mechanosensitivity and the kicking behavior. In addition, touching different regions of the wing margin elicits kicking directed precisely at the stimulated region. Our experiments suggest that recurved bristles allow the fly to sense the presence of objects by touch to initiate a defensive behavior (perhaps analogous to touch-evoked scratching; ).
机译：机械感觉是最快的感觉方式之一，它介导多种行为，包括与生存有关的行为。重要的是要了解机械刺激如何触发防御行为。在这里，我们报告果蝇果蝇表现出对他们的翼缘对入侵的寄生螨的踢反应，具有超快的速度和较高的空间精度。模拟螨虫运动的机械刺激引起类似的踢脚行为。此外，我们在每个弯曲的刷毛下沿着翼缘形成一个阵列，将TRPV通道Nanchung和一个特定的Nanchung表达神经元识别为该行为的重要感觉成分。我们的电生理记录表明，曲毛的机械敏感性需要南充和表达南充的神经元。在一起，我们的结果揭示了一种通过机械感觉进行先天防御行为的新型神经机制。>重要意义声明：我们发现了果蝇黑翼上弯曲的硬毛先前未知的功能。我们发现，当螨虫（果蝇的一种寄生虫）触碰到机翼边缘时，苍蝇会迅速而准确地踢出螨虫。飞头对于这种行为是必不可少的。此外，我们发现TRPV通道Nanchung和每个弯曲的鬃毛下的特定Nanchung表达神经元对其机械敏感性和踢动行为至关重要。另外，触摸机翼边缘的不同区域会导致将脚踢精确对准受刺激区域。我们的实验表明，弯曲的刷毛可以使苍蝇通过触摸来感知物体的存在，从而启动防御行为（也许类似于触摸诱发的刮擦；）。

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