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首页> 美国卫生研究院文献>The Journal of Neuroscience >Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action
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Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action

机译：灵长类动物腹侧苍白球的信号激励和驱动力用于目标控制性行动的动机控制

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Processing incentive and drive is essential for control of goal-directed behavior. The limbic part of the basal ganglia has been emphasized in these processes, yet the exact neuronal mechanism has remained elusive. In this study, we examined the neuronal activity of the ventral pallidum (VP) and its upstream area, the rostromedial caudate (rmCD), while two male macaque monkeys performed an instrumental lever release task in which a visual cue indicated the forthcoming reward size. We found that the activity of some neurons in VP and rmCD reflected the expected reward size transiently following the cue. Reward size coding appeared earlier and stronger in VP than in rmCD. We also found that the activity in these areas was modulated by the satiation level of monkeys, which also occurred more frequently in VP than in rmCD. The information regarding reward size and satiation level was independently signaled in the neuronal populations of these areas. The data thus highlighted the neuronal coding of key variables for goal-directed behavior in VP. Furthermore, pharmacological inactivation of VP induced more severe deficit of goal-directed behavior than inactivation of rmCD, which was indicated by abnormal error repetition and diminished satiation effect on the performance. These results suggest that VP encodes incentive value and internal drive and plays a pivotal role in the control of motivation to promote goal-directed behavior.>SIGNIFICANCE STATEMENT The limbic part of the basal ganglia has been implicated in the motivational control of goal-directed action. Here, we investigated how the ventral pallidum (VP) and the rostromedial caudate (rmCD) encode incentive value and internal drive and control goal-directed behavior. Neuronal recording and subsequent pharmacological inactivation revealed that VP had stronger coding of reward size and satiation level than rmCD. Reward size and satiation level were independently encoded in the neuronal population of these areas. Furthermore, VP inactivation impaired goal-directed behavior more severely than rmCD inactivation. These results highlight the central role of VP in the motivational control of goal-directed action.
机译：处理激励和驱动力对于控制目标导向的行为至关重要。在这些过程中已经强调了基底神经节的边缘部分，但是确切的神经元机制仍然难以捉摸。在这项研究中，我们检查了腹侧苍白球（VP）及其上游区域罗氏尾状尾核（rmCD）的神经元活动，而两只雄性猕猴则执行了工具杠杆释放任务，其中视觉提示指示了即将到来的奖励大小。我们发现，在提示后，VP和rmCD中某些神经元的活动反映了预期的奖励大小。奖励大小编码在VP中比rmCD出现得更早并且更强。我们还发现，这些区域的活动受到猴子饱食程度的调节，猴子的饱食程度也比VPCD发生得更频繁。在这些区域的神经元群体中，有关奖励大小和饱足程度的信息是独立发出的。因此，数据突显了VP中针对目标行为的关键变量的神经元编码。此外，VP的药理学失活比rmCD的失活引起更严重的目标定向行为缺陷，这由异常错误重复和对表现的饱足感降低所表明。这些结果表明，VP编码激励值和内部驱动力，并在控制动机以促进目标导向行为中起关键作用。>意义声明基底节的边缘部分与动机有关。控制目标导向的动作。在这里，我们研究了腹侧苍白球（VP）和罗氏尾状尾核（rmCD）如何编码激励值以及内部驱动和控制目标导向的行为。神经元记录和随后的药理学失活表明，与rmCD相比，VP具有更强的奖励大小和饱足程度编码。奖励的大小和饱足感水平在这些区域的神经元群体中独立编码。此外，与rmCD灭活相比，VP灭活更严重地损害了目标行为。这些结果凸显了VP在目标导向行动的动机控制中的核心作用。

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