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首页> 美国卫生研究院文献>Journal of Occupational Medicine and Toxicology (London England) >Uniform comparison of several drugs which provide protection from noise induced hearing loss
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Uniform comparison of several drugs which provide protection from noise induced hearing loss

机译：几种药物的统一比较这些药物可防止噪音引起的听力损失

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BackgroundThe ability of drugs to reduce noise induced hearing loss (NIHL) has been evaluated in diverse experimental conditions (animal species, noise intensities, durations, assessment techniques, etc), making it difficult to assess their relative efficacy. The present study was designed to provide more uniform comparisons and to allow to a better understanding of the mechanism of the NIHL. Methods: The drugs studied included furosemide (loop diuretic) and the antioxidants N Acetyl-L-Cysteine, vitamins A, C, E with the vasodilator magnesium. Mice were exposed to a continuous broadband noise (113 dB SPL for 3.5 hours) and the NIHL was assessed in all animals before noise exposure and 1 week after with auditory nerve brainstem evoked responses (ABR) to broadband clicks and to 8 kHz tone bursts.
机译：背景技术已经在多种实验条件（动物种类，噪声强度，持续时间，评估技术等）中评估了药物减少噪声诱发的听力损失（NIHL）的能力，这使得很难评估其相对功效。本研究旨在提供更统一的比较，并允许更好地了解NIHL的机制。方法：研究的药物包括速尿（利尿剂）和抗氧化剂N乙酰-L-半胱氨酸，维生素A，C，E和血管扩张剂镁。将小鼠暴露于连续的宽带噪声中（113 dB SPL持续3.5小时），并在噪声暴露之前和之后1周对所有动物进行NIHL评估，听觉神经脑干诱发对宽带点击和8 kHz音调猝发的反应（ABR）。

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