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Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells

机译：缺氧诱导因子-1α诱导卵巢癌细胞CX3CR1表达并促进上皮向间质转化（EMT）

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BackgroundChemokines are involved in the homing of various cancer cells, including those of ovarian cancer (OvCa), to distant organs. They may also promote or inhibit cancer progression and metastasis. Hypoxia, a common phenomenon in malignant tumors, promotes cell proliferation regulated by HIF-1α. Hypoxia-induced genes are involved in metastasis-associated functions and in the epithelial-to-mesenchymal transition (EMT).

机译：背景趋化因子参与各种癌细胞（包括卵巢癌（OvCa）的癌细胞）向远端器官的归巢。它们还可以促进或抑制癌症的进展和转移。缺氧是恶性肿瘤中的常见现象，可促进受HIF-1α调节的细胞增殖。缺氧诱导的基因参与与转移相关的功能以及上皮-间质转化（EMT）。

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期刊名称 Journal of Ovarian Research
作者
Santosh Kumar Singh; Manoj Kumar Mishra; Rajesh Singh;
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作者单位

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年(卷),期 2019(12),-1
年度 2019
页码 42
总页数 10
原文格式 PDF
正文语种
中图分类生理学;
关键词
Ovarian cancer Hypoxia Chemokines CX3CR1 EMT markers;

机译：卵巢癌;缺氧;趋化因子;CX3CR1;EMT标记;

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专利

1. Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells [J] . Santosh Kumar Singh, Manoj Kumar Mishra, Rajesh Singh Journal of Ovarian Research . 2019,第1期

机译：缺氧诱导因子-1α诱导CX3CR1表达并促进卵巢癌细胞中的间充质转换（EMT）的上皮
2. Stable expression of hypoxia-inducible factor-1α in human renal proximal tubular epithelial cells promotes epithelial to mesenchymal transition [J] . LuoL., LuoG., FangQ., Transplantation Proceedings . 2014,第1期

机译：缺氧诱导因子-1α在人肾近端肾小管上皮细胞中的稳定表达促进上皮向间质的转化
3. MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1α expression in third-sphere forming breast cancer stem cell-like cells [J] . HanM., WangY., LiuM., Cancer science. . 2012,第6期

机译：MiR-21调节形成第三球的乳腺癌干细胞样细胞中上皮-间质转化表型和低氧诱导因子-1α表达
4. PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-mesenchymal Transition [C] . Jiyu Ju, Wenjing Yu, Chunling Zhao International Conference on Applied Sciences, Engineering and Technology . 2014

机译：PLK1通过诱导上皮 - 间充质转换来促进食管鳞状细胞癌细胞的侵袭
5. Identifying Novel Inhibitors of Epithelial to Mesenchymal Transition (EMT) for Targeting Pancreatic Cancer Metastasis and Cancer Stem Cells [D] . Polireddy, Kishore. 2015

机译：确定靶向胰腺癌转移和癌症干细胞的新型上皮间质转化抑制剂（EMT）
6. Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1α is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery [O] . MINGSHENG HUANG, LONG WANG, JUNWEI CHEN, -1

机译：缺氧诱导因子-1α对COX-2表达和上皮向间充质转变的调节与TACE术后肝细胞癌患者预后不良相关
7. Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition [O] . Sun Shiren, Ning Xiaoxuan, Zhang Yanqi, 2009

机译：缺氧诱导因子-1α诱导缺氧的肾小管上皮细胞Twist表达，导致上皮向间充质转化

Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells

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