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首页> 美国卫生研究院文献>Journal of Ovarian Research >Impact of the addition of Early Embryo Viability Assessment to morphological evaluation on the accuracy of embryo selection on day 3 or day 5: a retrospective analysis
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Impact of the addition of Early Embryo Viability Assessment to morphological evaluation on the accuracy of embryo selection on day 3 or day 5: a retrospective analysis

机译：回顾性分析：在第3天或第5天将早期胚胎生存力评估添加到形态学评估中对胚胎选择准确性的影响

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In this study we aimed at retrospectively assessing in a homogeneous group of IVF patients whether the addition of Early Embryo Viability Assessment (Eeva™) to standard morphology increases the accuracy of embryo selection in case of double embryo transfer (DET) on day 3 or single embryo transfer (SET) on day 5. Eeva™ is an algorhythm aimed at indicating on day 3, according to morphokinetic parameters observed in the first three days of embryo growth, which embryos are more likely to develop into viable blastocysts and implant. A total number of 328 patients were included in the study; IVF or ICSI were performed and 428 embryos were transferred, either with DET on day 5, or (when at least four top scored embryos were available on day 3) with SET of day 5. Four groups were considered: (a) patients receiving day 3 DET with embryos selected by standard morphology (DET-3 M, n = 106, receiving 212 embryos), (b) patients receiving day 3 DET with embryos selected by morphology plus Eeva™ (DET-3 ME group, n = 48, receiving 96 embryos), (c) patients receiving day 5 SET with a blastocyst selected by standard morphology (SET-5 M group, n = 126, receiving 126 embryos), and (d) patients receiving day 5 SET with a blastocyst selected by morphology plus Eeva™ (SET-5 ME group, n = 48, receiving 48 embryos). Overall, a clinical pregnancy rate of 49.1%, implantation rate of 40%, and ongoing pregnancy rate of 43.6% were observed. The implantation rate was significantly higher in DET-3 ME group than in DET-3 M group (44.8% vs. 30.2%, p < 0.02), whereas it was comparable in groups DET-3 ME, SET-5 M and SET-5 ME. Differently, the ultrasound-verified clinical pregnancy rate and the ongoing pregnancy rate at 12 weeks did not significantly differ in all four groups. Overall, our findings suggest that Eeva™ algorhythm can improve embryo selection accuracy of standard morphology when ET on day 3 is scheduled, leading to a higher implantation rate, but its impact on ongoing pregnancy and live birth needs to be further clarified.
机译：在这项研究中，我们旨在回顾性评估一组IVF患者，将早期胚胎生存力评估（Eeva™）添加到标准形态中是否增加了在第3天或两次胚胎移植（DET）的情况下胚胎选择的准确性。胚胎移植（SET）在第5天。根据胚胎生长的前三天观察到的形态动力学参数，Eeva™是旨在指示第3天的算法，该胚胎更可能发育成有活力的胚泡和植入物。该研究共纳入328名患者；进行了IVF或ICSI，并在第5天用DET或（在第3天至少有四个得分最高的胚胎可用）第5天的SET进行了428个胚胎的移植。考虑了四组：（a）接受治疗的患者3个具有标准形态选择的胚胎的DET（DET-3 M，n = 106，接受212个胚胎），（b）接受第3天DET的形态和Eeva™胚胎选择的患者（DET-3 ME组，n == 48，接受96个胚胎），（c）接受第5天SET并通过标准形态选择了胚泡的患者（SET-5 M组，n = 126，接受126个胚胎），以及（d）接受第5天SET并选择了胚泡的患者形态学和Eeva™（SET-5 ME组，n == 48，接受48个胚胎）。总体而言，观察到临床妊娠率为49.1％，着床率为40％，持续妊娠率为43.6％。 DET-3 ME组的植入率显着高于DET-3 M组（44.8％比30.2％，p <0.02），而在DET-3 ME，SET-5 andM和SET-组中可比。 5 ME。不同的是，在所有四个组中，超声验证的临床妊娠率和12周时的持续妊娠率均无显着差异。总体而言，我们的发现表明，当计划在第3天进行ET时，Eeva™算法可以提高标准形态的胚胎选择准确性，从而提高植入率，但需要进一步阐明其对正在进行的妊娠和活产的影响。

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