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首页> 美国卫生研究院文献>Balkan Journal of Medical Genetics : BJMG >Does the A9285G Polymorphism in Collagen Type XII α1 Gene Associate with the Risk of Anterior Cruciate Ligament Ruptures?
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Does the A9285G Polymorphism in Collagen Type XII α1 Gene Associate with the Risk of Anterior Cruciate Ligament Ruptures?

机译：XII型胶原α1基因的A9285G多态性是否与前十字韧带破裂的风险相关？

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摘要

One of the most severe injuries sustained by athletes is rupture of the anterior cruciate ligament (ACL). Recent investigations suggest that a predisposition for ACL rupture may be the result of specific genetic sequence variants. In light of this, we decided to investigate whether the COL12A1 A9285G polymorphism was associated with ACL ruptures in Polish football players.We compared genotypic and allelic frequencies of the COL12A1 A9285G polymorphism in two groups of athletes: 91 male football players (23 ± 3 years) with surgically diagnosed primary ACL ruptures who qualified for ligament reconstruction (cases) and 143 apparently healthy, male football players of the same ethnicity, a similar age category, and a comparable level of exposure to ACL injury, who were without any self-reported history of ligament or tendon injury (controls). DNA samples extracted from the oral epithelial cells were genotyped by using a real-time polymerase chain reaction (Ri-Ti-PCR) method.The genotype distribution in the cases were not different from those in controls (p = 0.70). The frequency of the G allele was lower in the cases (18.1%) but not statistically significant (p = 0.40) when compared with controls (21.3%).Our results are in contradiction to the hypothesis that the COL12A1 A9285G polymorphism is associated with a predisposition for ACL injury. However, these conclusions should be supported with more experimental studies on COL12A1 polymorphisms.
机译：运动员遭受的最严重的伤害之一是前十字韧带（ACL）破裂。最近的研究表明，ACL破裂的易感性可能是特定基因序列变异的结果。有鉴于此，我们决定调查COL12A1 A9285G多态性是否与波兰足球运动员的ACL断裂有关。我们比较了两组运动员中COL12A1 A9285G多态性的基因型和等位基因频率：91名男性足球运动员（23±3岁） ）经手术诊断的原发性ACL破裂并具有韧带重建的资格（病例），并且有143名显然健康的，相同种族，相似年龄类别，并且具有相当水平的ACL损伤暴露的男性足球运动员，但没有任何自我报告韧带或肌腱损伤史（对照）。使用实时聚合酶链反应（Ri-Ti-PCR）方法对从口腔上皮细胞中提取的DNA样本进行基因分型，病例中的基因型分布与对照组无差异（p = 0.70）。与对照组（21.3％）相比，病例中G等位基因的频率较低（18.1％），但无统计学意义（p = 0.40）。我们的结果与COL12A1 A9285G多态性与AOL相关的假设相矛盾。 ACL损伤的易感性。但是，这些结论应得到有关COL12A1多态性的更多实验研究的支持。

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