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首页> 美国卫生研究院文献>Antioxidants >Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors
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Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors

机译：李属和李属叶精油作为抗氧化剂和胆碱酯酶抑制剂的潜在应用

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The aim of this work is to investigate the in vitro acetylcholinesterase (AChE) and butyrycholinesterase (BChE) inhibitory activities of essential oils obtained by hydrodistillation from the leaves of Prunus armeniaca and P. domestica in relation to their composition, analysed by Gas Chromatography–Flame Ionization Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS) analyses, at different times. Moreover, considering the role of free radicals in the progression of neurodegenerative disorders, the antioxidant properties of essential oils were investigated by using, 2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and β-carotene bleaching tests. The relative antioxidant capacity index (RACI) was used to achieve more comprehensive comparison between analysed antioxidant effects of essential oils. P. armeniaca oils were more active than P. domestica oils against AChE. Against BChE, the most active was the essential oil from P. domestica leaves collected in August with an IC50 value of 95.80 μg/mL. This oil exerted the highest inhibitory activity of lipid peroxidation with IC50 values of 11.15 and 11.39 μg/mL after 30 and 60 min of incubation, respectively. All samples demonstrated a remarkable ABTS radicals scavenging activity, with IC50 values in the range 0.45–0.57 μg/mL in comparison to the positive control, ascorbic acid.
机译：这项工作的目的是研究通过加氢蒸馏从杏李和P. domestica的叶片中蒸馏得到的精油的体外乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制活性与其成分的关系，并通过气相色谱-火焰分析电离检测器（GC-FID）和气相色谱-质谱（GC-MS）分析在不同的时间进行。此外，考虑到自由基在神经退行性疾病发展中的作用，通过使用2'-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）（ABTS），2,2-研究了香精油的抗氧化性能。二苯基-1-吡啶并肼（DPPH）和β-胡萝卜素漂白测试。相对抗氧化能力指数（RACI）用于在精油的抗氧化效果之间进行更全面的比较。相比于家蝇，A。Armeniaca油对AChE的活性更高。针对BChE，最活跃的是八月份从家蝇叶中提取的精油，IC50值为95.80μg/ mL。孵育30分钟和60分钟后，该油具有最高的脂质过氧化抑制活性，IC50值分别为11.15和11.39μg/ mL。与阳性对照抗坏血酸相比，所有样品均表现出显着的ABTS自由基清除活性，IC50值在0.45-0.57μg/ mL范围内。

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